Titre
Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Jara-Palomares, L.
Auteure/Auteur
Alfonso, M.
Auteure/Auteur
Maestre, A.
Auteure/Auteur
Jimenez, D.
Auteure/Auteur
Garcia-Bragado, F.
Auteure/Auteur
Font, C.
Auteure/Auteur
Reyes, R.L.
Auteure/Auteur
Blasco, L.H.
Auteure/Auteur
Vidal, G.
Auteure/Auteur
Otero, R.
Auteure/Auteur
Monreal, M.
Auteure/Auteur
Contributrices/contributeurs
Adarraga, M.D.
Aibar, M.Á.
Aibar, J.
Amado, C.
Arcelus, J.I.
Ballaz, A.
Barba, R.
Barrón, M.
Barrón-Andrés, B.
Bascuñana, J.
Blanco-Molina, Á.
Camón, A.M.
Cañas, I.
Carrasco, C.
Castro, J.
de Ancos, C.
Del Toro, J.
Demelo, P.
Díaz-Peromingo, J.A.
Díaz-Simón, R.
Falgá, C.
Farfán, A.I.
Fernández-Capitán, C.
Del Carmen Fernández-Criado, M.
Fernández-Núñez, S.
Fidalgo, Á.
Font, L.
García, M.A.
García-Morillo, M.
García-Raso, A.
Gavín-Sebastián, O.
Del Carmen Gayol, M.
Gil-Díaz, A.
Gómez, V.
Gómez-Cuervo, C.
González-Martínez, J.
Grau, E.
Gutiérrez, J.
Gutiérrez-González, S.
Iglesias, M.
Jaras, M.J.
Jou, I.
Joya, M.D.
Lalueza, A.
Lima, J.
Llamas, P.
Lobo, J.L.
López-Jiménez, L.
López-Miguel, P.
López-Núñez, J.J.
López-Sáez, J.B.
Lorente, M.A.
Lorenzo, A.
Loring, M.
Madridano, O.
Marchena, P.J.
Martín, J.M.
Mellado, M.
Morales, MDV
Nieto, M.L.
Nieto, J.A.
Núñez, M.J.
Olivares, M.C.
Pedrajas, J.M.
Pellejero, G.
Pérez-Rus, G.
Peris, M.L.
Porras, J.A.
Rivas, A.
Rodríguez-Dávila, M.Á.
Adela Rodríguez-Hernández, A.
Rubio, C.M.
Ruiz-Artacho, P.
Ruiz-Ruiz, J.
Ruiz-Sada, P.
Sahuquillo, J.C.
Salazar, V.
Sampériz, Á.
Muñoz-Torrero, JFS
Sancho, T.
Soler, S.
Suriñach, J.M.
Tapia, E.
Tolosa, C.
Torres, M.I.
Trujillo-Santos, J.
Uresandi, F.
Valle, R.
Villares, P.
Gutiérrez, P.
Vázquez, F.J.
Vilaseca, A.
Vanassche, T.
Vandenbriele, C.
Verhamme, P.
Hirmerova, J.
Malý, R.
Celis, G.
Del Pozo, G.
Salgado, E.
Benzidia, I.
Bertoletti, L.
Bura-Riviere, A.
Debourdeau, P.
Farge-Bancel, D.
Hij, A.
Mahé, I.
Moustafa, F.
Schellong, S.
Braester, A.
Brenner, B.
Tzoran, I.
Sharif-Kashani, B.
Barillari, G.
Bilora, F.
Bortoluzzi, C.
Brandolin, B.
Bucherini, E.
Ciammaichella, M.
Dentali, F.
Di Micco, P.
Maida, R.
Mastroiacovo, D.
Mumoli, N.
Pace, F.
Parisi, R.
Pesavento, R.
Prandoni, P.
Quintavalla, R.
Rocci, A.
Romualdi, R.
Sinicalchi, C.
Tufano, A.
Visonà, A.
Hong, N.V.
Zalunardo, B.
Gibietis, V.
Kigitovica, D.
Skride, A.
Bosevski, M.
Bounameaux, H.
Mazzolai, L.
Caprini, J.A.
Bui, H.M.
Pham, K.Q.
Reis, A.
Groupes de travail
RIETE investigators
Liens vers les personnes
Liens vers les unités
ISSN
2045-2322
Statut éditorial
Publié
Date de publication
2019-12-27
Volume
9
Numéro
1
Première page
20064
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
In young patients with acute pulmonary embolism (PE), the predictive value of currently available prognostic tools has not been evaluated. Our objective was to compare prognostic value of 7 available tools (GPS, PESI, sPESI, Prognostic Algorithm, PREP, shock index and RIETE) in patients aged <50 years. We used the RIETE database, including PE patients from 2001 to 2017. The major outcome was 30-day all-cause mortality. Of 34,651 patients with acute PE, 5,822 (17%) were aged <50 years. Of these, 83 (1.4%) died during the first 30 days. Number of patients deemed low risk with tools was: PREP (95.9%), GPS (89.6%), PESI (87.2%), Shock index (70.9%), sPESI (59.4%), Prognostic algorithm (58%) and RIETE score (48.6%). The tools with a highest sensitivity were: Prognostic Algorithm (91.6%; 95% CI: 85.6-97.5), RIETE score (90.4%; 95%CI: 84.0-96.7) and sPESI (88%; 95% CI: 81-95). The RIETE, Prognostic Algorithm and sPESI scores obtained the highest overall sensitivity estimates for also predicting 7- and 90-day all-cause mortality, 30-day PE-related mortality, 30-day major bleeding and 30-day VTE recurrences. The proportion of low-risk patients who died within the first 30 days was lowest using the Prognostic Algorithm (0.2%), RIETE (0.3%) or sPESI (0.3%) scores. In PE patients less 50 years, 30-day mortality was low. Although sPESI, RIETE and Prognostic Algorithm scores were the most sensitive tools to identify patients at low risk to die, other tools should be evaluated in this population to obtain more efficient results.
PID Serval
serval:BIB_B17B0EBEA223
PMID
Open Access
Oui
Date de création
2020-11-26T11:17:37.706Z
Date de création dans IRIS
2025-05-20T23:42:02Z
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Nom
41598_2019_Article_55213.pdf
Version du manuscrit
preprint
Licence
https://creativecommons.org/licenses/by/4.0
Taille
1.28 MB
Format
Adobe PDF
PID Serval
serval:BIB_B17B0EBEA223.P001
Somme de contrôle
(MD5):e6578c3f7bb23afe39c5a3633c8b51fc