Titre
Prediction of ROP Treatment and Evaluation of Screening Criteria in VLBW Infants-a Population Based Analysis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Gerull, R.
Auteure/Auteur
Brauer, V.
Auteure/Auteur
Bassler, D.
Auteure/Auteur
Laubscher, B.
Auteure/Auteur
Pfister, R.E.
Auteure/Auteur
Nelle, M.
Auteure/Auteur
Müller, B.
Auteure/Auteur
Roth-Kleiner, M.
Auteure/Auteur
Gerth-Kahlert, C.
Auteure/Auteur
Adams, M.
Auteure/Auteur
Contributrices/contributeurs
Anderegg, C.
Meyer, P.
Mori, A.C.
Kaeppeli, D.
Schulzke, S.
Weber, P.
Ramelli, G.P.
Nelle, M.
Wagner, B.
Steinlin, M.
Grunt, S.
Hassink, R.
Riedel, T.
Keller, E.
Killer, C.
Fuhrer, K.
Tolsa, J.F.
Roth-Kleiner, M.
Bickle-Graz, M.
Pfister, R.E.
Huppi, P.S.
Borradori-Tolsa, C.
Stocker, M.
Schmitt-Mechelke, T.
Bauder, F.
Pezzoli, V.
Erkert, B.
Mueller, A.
Ecoffey, M.
Malzacher, A.
Lang-Dullenkopf, A.
Micallef, J.P.
Hegi, L.
von Rhein, M.
Arlettaz, R.
Bassler, D.
Bernet, V.
Latal, B.
Natalucci, G.
Groupes de travail
Swiss Neonatal Network & Follow-up Group
Liens vers les personnes
Liens vers les unités
ISSN
1530-0447
Statut éditorial
Publié
Date de publication
2018-11
Volume
84
Numéro
5
Première page
632
Dernière page/numéro d’article
638
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
The incidence of retinopathy of prematurity (ROP) and ROP screening criteria differ between countries. We assessed whether ROP screening could be reduced based on the local ROP incidence.
Observational cohort study of infants born in Switzerland between 2006 and 2015 <32 0/7 weeks. Chronological and postmenstrual ages at ROP treatment were analyzed. A model to identify ROP treatment on patients born between 2006 and 2012 (training set) was developed and tested on patients born between 2013 and 2015 (validation set).
Of 7817 live-born infants, 1098 died within the first 5 weeks of life. The remaining 6719 infants were included into analysis. All patients requiring ROP treatment would have been identified if screening had been performed before reaching 60 days of life or 37 3/7 weeks postmenstrual age, whichever came first. The training and validation sets included 4522 and 2197 preterm infants encompassing 56 and 20 patients receiving ROP treatment, respectively. All patients would have required screening to reach 100% sensitivity. To reach a sensitivity of 95.0% and a specificity of 87.6%, we predicted a reduction in 13.2% of patients requiring screening (c-statistic = 0.916).
A substantial reduction of infants requiring screening seems possible, but necessitates prospective testing of new screening criteria.
Observational cohort study of infants born in Switzerland between 2006 and 2015 <32 0/7 weeks. Chronological and postmenstrual ages at ROP treatment were analyzed. A model to identify ROP treatment on patients born between 2006 and 2012 (training set) was developed and tested on patients born between 2013 and 2015 (validation set).
Of 7817 live-born infants, 1098 died within the first 5 weeks of life. The remaining 6719 infants were included into analysis. All patients requiring ROP treatment would have been identified if screening had been performed before reaching 60 days of life or 37 3/7 weeks postmenstrual age, whichever came first. The training and validation sets included 4522 and 2197 preterm infants encompassing 56 and 20 patients receiving ROP treatment, respectively. All patients would have required screening to reach 100% sensitivity. To reach a sensitivity of 95.0% and a specificity of 87.6%, we predicted a reduction in 13.2% of patients requiring screening (c-statistic = 0.916).
A substantial reduction of infants requiring screening seems possible, but necessitates prospective testing of new screening criteria.
PID Serval
serval:BIB_AECC54DF1BAF
PMID
Date de création
2019-10-02T19:16:57.820Z
Date de création dans IRIS
2025-05-20T22:09:35Z