Titre
Pneumopathie organisee cryptogenique.
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Lazor, R.
Auteure/Auteur
Liens vers les personnes
ISSN
0761-8417
Statut éditorial
Publié
Date de publication
2005-06
Volume
61
Numéro
3
Première page
193
Dernière page/numéro d’article
202
Peer-reviewed
Oui
Notes
English Abstract
Journal Article
Review
Journal Article
Review
Résumé
Organising Pneumonia (formerly called Bronchiolitis Obliterans with Organising Pneumonia) is a particular form of inflammatory and fibroproliferative lung disease. Its idiopathic form called Cryptogenic Organising Pneumonia, was recently defined by an ATS/ERS consensus conference. The disease onset is subacute with cough, dyspnea, fever, asthenia, weight loss, crackles, and elevation of biological inflammatory markers. Bronchoalveolar lavage reveals a mixed alveolitis with elevated lymphocyte, neutrophil, and eosinophil counts. Chest imaging usually shows multifocal alveolar opacities predominating in the subpleural regions, often with a migratory pattern. Lung biopsy reveals budding connective tissue filling the distal airspaces. Diagnosis is established by combining clinical, radiological and histological criteria. Similarities with other disease processes can lead to delayed or erroneous diagnosis. Most patients respond well to corticosteroid therapy. Relapses are frequent but can generally be controlled with moderate doses of prednisone and do not worsen the prognosis. The therapeutic strategy aims at reducing the steroid doses while maintaining an optimal disease control.
Sujets
PID Serval
serval:BIB_2D4DD65644A7
PMID
Date de création
2008-12-19T10:58:57.979Z
Date de création dans IRIS
2025-05-20T17:27:43Z