Titre
Multiple courses of antenatal corticosteroids for preterm birth study: outcomes in children at 5 years of age (MACS-5).
Type
article
Institution
Externe
Périodique
Auteur(s)
Asztalos, E.V.
Auteure/Auteur
Murphy, K.E.
Auteure/Auteur
Willan, A.R.
Auteure/Auteur
Matthews, S.G.
Auteure/Auteur
Ohlsson, A.
Auteure/Auteur
Saigal, S.
Auteure/Auteur
Armson, B.A.
Auteure/Auteur
Kelly, E.N.
Auteure/Auteur
Delisle, M.F.
Auteure/Auteur
Gafni, A.
Auteure/Auteur
Lee, S.K.
Auteure/Auteur
Sananes, R.
Auteure/Auteur
Rovet, J.
Auteure/Auteur
Guselle, P.
Auteure/Auteur
Amankwah, K.
Auteure/Auteur
Saleem, M.
Auteure/Auteur
Sanchez, J.
Auteure/Auteur
Contributrices/contributeurs
Asztalos, EV.
Murphy, K.
Willan, A.
Matthews, S.
Hannah, M.
Ohlsson, A.
Kelly, E.
Saigal, S.
Ross, S.
Delisle, M.
Amankwah, K.
Guselle, P.
Gafni, A.
Lee, S.
Armson, B.
Sananes, R.
Rovet, J.
Sanchez, J.
Saleem, M.
Asztalos, E.
Murphy, K.
Saigal, S.
Bracken, M.
Crowley, P.
Thorpe, K.
Duley, L.
Erenkranz, R.
Kavuma, E.
Saleem, M.
Tobin, S.
Shi, M.
Chan, S.
Gubatan, J.
Cardwell, J.
Leung, M.
Sanchez, J.
Mason, D.
Kwiatkowski, L.
Deguer, C.
Salazar, A.
Brindo, M.
Klun, M.
Castaldi, JL.
Bertin, MS.
Rodriguez, D.
Fustiñana, CA.
Otaño, L.
Izbizky, G.
Palermo, MS.
Varela, DM.
García£££María Valeria£££ MV.,
Trasmonte, ME.
Basualdo, MN.
Schapira, I.
Andina, E.
Di Marco, I.
Aspres, N.
Rivero, M.
Gomez, EE.
Palacios, LL.
Ahlbom, MB.
Bonassies, MS.
Vidal, DA.
Aguirre, JD.
Morales, EM.
Garcia, SA.
Abreo, GI.
De Sagastizabal MT.,
Martin Rde, L.
De Gaetano SL.,
Walter, M.
Arias, C.
Farri, ML.
Gorostiaga, RA.
Alvarado, JE.
Curioni, M.
Tessari, DM.
Madi, JM.
Zatti, H.
Mattana Mdo, C.
Ártico, Gl.
Trapani A.<Suffix>Jr</Suffix>,
Finger, TC.
Rosado£££Luiza Emylce Pelᣣ£ LE.,
Teixeira, VR.
Vidal, AC.
de Souza GR.,
de Sa RA.,
Bornia, RG.
Hendson, L.
Tomlinson, J.
Demianczuk, N.
Penttinen, E.
Krishnaswamy, R.
Paquin, J.
Butt, K.
Hay, K.
Beaney, A.
Armson, A.
Allen, V.
Fanning, C.
Kulkarni, R.
Laplante, J.
Carson, GD.
Williams, S.
Olatunbosun, F.
Henry, A.
Wonko, N.
Moutquin, JM.
Ferretti, E.
Royer, D.
Blouin, D.
Bédard, SK.
Murphy, K.
Ohlsson, A.
Kelly, E.
Rovet, J.
Sananes, R.
Asztalos, E.
Cohen, H.
Barrett, J.
Hohn, D.
Lacy, M.
Delisle, MF.
Quelch, S.
Willar, T.
Synnes, A.
Butt, A.
Hubber-Richard, P.
Moddemann, D.
Cote, D.
Kenny-Lodewyks, D.
Helewa, M.
del Rio, S.
Gomez, R.
Neculman, KS.
Vargas, P.
Pons, A.
Kusanovic, JP.
Veloso, PP.
Aguilera, LS.
Schifferli, MT.
Gonzalez, PU.
Poblete, JF.
Ferrand, P.
Reyes, AB.
Moore, R.
Belmar, C.
Ortiz, EI.
Munoz, JT.
Sanchez, A.
Jimenez, CA.
Atencia, D.
Hvidman, L.
Mouritzen, A.
Vikre-Jørgensen, J.
Nonnenmacher, A.
Hopp, H.
Hoyme, UB.
Bittrich, HJ.
Oletzky, B.
Dressler, F.
Hollwitz, B.
Korausova, J.
Krause, M.
Petermoeller, M.
Mueller, K.
Major£££Tamás£££ T.,
Bartha, T.
Krasznai£££Zoárd£££ Z.,
Nachum, Z.
Faranesh, R.
Galil, A.
Hallak, M.
Adiva, H.
Harel, L.
Chayen, B.
Wolff, L.
Samberg, I.
Gonen, R.
Wolfson, E.
Kohelet, D.
Shochot, R.
Arbel, E.
Sadan, O.
Regev, R.
Zausmer, J.
Kaneti, H.
Rosen, D.
Netter, T.
Klinger, G.
Tirosh£££Na'ama£££ N.,
Naor, N.
Maman, M.
El-Zibdeh, M.
Al-Faris, L.
Preis, K.
Domzalska-Popadiuk, I.
Thrun, A.
Kobiela, P.
Swiatkowska-Freund, M.
Preis-Ortikowska, J.
Janczewska, I.
Kesiak, M.
Krekora, M.
Zych, K.
Wilczynski, J.
Gulczyńska, E.
Krasomski, G.
Breborowicz, G.
Szymankiewicz, M.
Rozycka, J.
Montgomery, A.
Ropacka, M.
Madejczyk, M.
Samsonova, T.
Malyshkina, A.
Borzova, N.
Chasha, T.
Khodzhaeva, Z.
Vikhlyaeva, E.
Grande, M.
Botet, F.
Palacio, M.
Weber, P.
Tillmann, B.
Hosli, I.
Forcada-Guex, M.
Hohlfeld, P.
Prince-dit-Clottu, E.
Belhia, F.
Roumen, FJ.
Gavilanes, AW.
Smits, F.
Bolaji, I.
Groupes de travail
MACS-5 Collaborative Group
Liens vers les personnes
ISSN
2168-6211
Statut éditorial
Publié
Date de publication
2013
Volume
167
Numéro
12
Première page
1102
Dernière page/numéro d’article
1110
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
IMPORTANCE: A single course of antenatal corticosteroid therapy is recommended for pregnant women at risk of preterm birth between 24 and 33 weeks' gestational age. However, 50% of women remain pregnant 7 to 14 days later, leading to the question of whether additional courses should be given to women remaining at risk for preterm birth. The Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study (MACS) was an international randomized clinical trial that compared multiple courses of antenatal corticosteroids with a single course in women at risk of preterm birth.
OBJECTIVE: To determine the effects of single vs multiple courses of antenatal corticosteroid therapy on death or neurodevelopmental disability (neuromotor, neurosensory, or neurocognitive/neurobehavioral function) at 5 years of age in children whose mothers participated in MACS. Our secondary aims were to determine the effect on height, weight, head circumference, blood pressure, intelligence, and specific cognitive (visual, spatial, and language) skills.
DESIGN, SETTING, AND PARTICIPANTS: Cohort follow-up study of children seen between June 2006 and May 2012 at 55 centers. In total, 1724 women (2141 children) were eligible for the study, of whom 1728 children (80.7% of the 2141 eligible children) participated and 1719 children contributed to the primary outcome.
INTERVENTION: Single and multiple courses of antenatal corticosteroid therapy.
MAIN OUTCOMES AND MEASURES: The primary outcome was death or survival with a neurodevelopmental disability in 1 of the following domains: neuromotor (nonambulatory cerebral palsy), neurosensory (blindness, deafness, or need for visual/hearing aids), or neurocognitive/neurobehavioral function (abnormal attention, memory, or behavior).
RESULTS: There was no significant difference between the groups in the risk of death or neurodevelopmental disability: 217 of 871 children (24.9%) in the multiple-courses group vs 210 of 848 children (24.8%) in the single-course group (odds ratio, 1.02 [95% CI, 0.81 to 1.29]; P = .84).
CONCLUSIONS AND RELEVANCE: Multiple courses, compared with a single course, of antenatal corticosteroid therapy did not increase or decrease the risk of death or disability at 5 years of age. Because of a lack of strong conclusive evidence of short-term or long-term benefits, it remains our opinion that multiple courses not be recommended in women with ongoing risk of preterm birth.
TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00187382.
OBJECTIVE: To determine the effects of single vs multiple courses of antenatal corticosteroid therapy on death or neurodevelopmental disability (neuromotor, neurosensory, or neurocognitive/neurobehavioral function) at 5 years of age in children whose mothers participated in MACS. Our secondary aims were to determine the effect on height, weight, head circumference, blood pressure, intelligence, and specific cognitive (visual, spatial, and language) skills.
DESIGN, SETTING, AND PARTICIPANTS: Cohort follow-up study of children seen between June 2006 and May 2012 at 55 centers. In total, 1724 women (2141 children) were eligible for the study, of whom 1728 children (80.7% of the 2141 eligible children) participated and 1719 children contributed to the primary outcome.
INTERVENTION: Single and multiple courses of antenatal corticosteroid therapy.
MAIN OUTCOMES AND MEASURES: The primary outcome was death or survival with a neurodevelopmental disability in 1 of the following domains: neuromotor (nonambulatory cerebral palsy), neurosensory (blindness, deafness, or need for visual/hearing aids), or neurocognitive/neurobehavioral function (abnormal attention, memory, or behavior).
RESULTS: There was no significant difference between the groups in the risk of death or neurodevelopmental disability: 217 of 871 children (24.9%) in the multiple-courses group vs 210 of 848 children (24.8%) in the single-course group (odds ratio, 1.02 [95% CI, 0.81 to 1.29]; P = .84).
CONCLUSIONS AND RELEVANCE: Multiple courses, compared with a single course, of antenatal corticosteroid therapy did not increase or decrease the risk of death or disability at 5 years of age. Because of a lack of strong conclusive evidence of short-term or long-term benefits, it remains our opinion that multiple courses not be recommended in women with ongoing risk of preterm birth.
TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00187382.
PID Serval
serval:BIB_DFCBD78709DD
PMID
Open Access
Oui
Date de création
2014-01-31T13:32:47.457Z
Date de création dans IRIS
2025-05-21T05:13:02Z