Titre
Transient stimulation of glucose metabolism by insulin in the 1-day chick embryo.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Baroffio, A.
Auteure/Auteur
Raddatz, E.
Auteure/Auteur
Markert, M.
Auteure/Auteur
Kucera, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0021-9541
Statut éditorial
Publié
Date de publication
1986
Volume
127
Numéro
2
Première page
288
Dernière page/numéro d’article
292
Langue
anglais
Résumé
Effects of insulin upon glucose metabolism were investigated in chick embryos explanted in vitro during the first 30 h of incubation. Insulin stimulated the glucose consumption of the chick gastrula (18 h) and neurula (24 h), but had no effect on the late blastula (0 h:laying) and on the stage of six to eight somites (30 h). The increase in glucose consumption concerned both the embryonic area pellucida (AP) and extraembryonic area opaca (AO). AP responded to a greater extent (50%) and at a lower range of concentrations (0.1-1.0 ng/ml) than AO (30%; 1-100 ng/ml). Insulin had no effect on the oxygen consumption of blastoderms, whereas it stimulated the aerobic lactate production (approximately 70% of the additional glucose consumption was converted to lactate). The nanomolar range of stimulating concentrations suggests that insulin has a specific effect in the chick embryo, and that it could modulate glucose metabolism in ovo as well. The transient sensitivity of the embryo to insulin is discussed in relation to behavior of mesodermal cells.
PID Serval
serval:BIB_07E60A6AA8BE
PMID
Date de création
2008-01-24T12:19:41.013Z
Date de création dans IRIS
2025-05-20T15:19:11Z