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  4. Brain pathology in focal status epilepticus: evidence from experimental models.
 
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Titre

Brain pathology in focal status epilepticus: evidence from experimental models.

Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Neuroscience & Biobehavioral Reviews  
Auteur(s)
de Curtis, M.
Auteure/Auteur
Rossetti, A.O.
Auteure/Auteur
Verde, D.V.
Auteure/Auteur
van Vliet, E.A.
Auteure/Auteur
Ekdahl, C.T.
Auteure/Auteur
Liens vers les personnes
Rossetti, Andrea  
Liens vers les unités
Recherche en neurosciences  
ISSN
1873-7528
Statut éditorial
Publié
Date de publication
2021-12
Volume
131
Première page
834
Dernière page/numéro d’article
846
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Status Epilepticus (SE) is often a neurological emergency characterized by abnormally sustained, longer than habitual seizures. The new ILAE classification reports that SE "…can have long-term consequences including neuronal death, neuronal injury…depending on the type and duration of seizures". While it is accepted that generalized convulsive SE exerts detrimental effects on the brain, it is not clear if other forms of SE, such as focal non-convulsive SE, leads to brain pathology and contributes to long-term deficits in patients. With the available clinical and experimental data, it is hard to discriminate the specific action of the underlying SE etiologies from that exerted by epileptiform activity. This information is highly relevant in the clinic for better treatment stratification, which may include both medical and surgical intervention for seizure control. Here we review experimental studies of focal SE, with an emphasis on focal non-convulsive SE. We present a repertoire of brain pathologies observed in the most commonly used animal models and attempt to establish a link between experimental findings and human condition(s). The extensive literature on focal SE animal models suggest that the current approaches have significant limitations in terms of translatability of the findings to the clinic. We highlight the need for a more stringent description of SE features and brain pathology in experimental studies in animal models, to improve the accuracy in predicting clinical translation.
Sujets

Animals

Brain/pathology

Disease Models, Anima...

Humans

Seizures

Status Epilepticus/dr...

Status Epilepticus/pa...

Animal models

Brain damage

Epilepsy

Gliosis

Status epilepticus

PID Serval
serval:BIB_848D0A1620FE
DOI
10.1016/j.neubiorev.2021.09.011
PMID
34517036
WOS
000707476500005
Permalien
https://iris.unil.ch/handle/iris/182924
Date de création
2021-09-21T09:40:24.200Z
Date de création dans IRIS
2025-05-21T01:09:17Z
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