Titre
Long-Term Consequences of COVID-19: A 1-Year Analysis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Bamps, L.
Auteure/Auteur
Armenti, J.P.
Auteure/Auteur
Bojan, M.
Auteure/Auteur
Grandbastien, B.
Auteure/Auteur
von Garnier, C.
Auteure/Auteur
Du Pasquier, R.
Auteure/Auteur
Desgranges, F.
Auteure/Auteur
Papadimitriou-Olivgeris, M.
Auteure/Auteur
Alberio, L.
Auteure/Auteur
Preisig, M.
Auteure/Auteur
Schwitter, J.
Auteure/Auteur
Guery, B.
Auteure/Auteur
Groupes de travail
The RegCOVID Study Group
ISSN
2077-0383
Statut éditorial
Publié
Date de publication
2023-04-03
Volume
12
Numéro
7
Première page
2673
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Long-lasting symptoms after SARS-CoV-2 infection have been described many times in the literature and are referred to as Long COVID. In this prospective, longitudinal, monocentric, observational study, we collected the health complaints of 474 patients (252 ambulatory and 222 hospitalized) at Lausanne University Hospital 1 year after COVID-19 diagnosis. Using a self-reported health survey, we explored cardiopulmonary, vascular, neurological, and psychological complaints. Our results show that age, Charlson comorbidity index, and smoking habits were associated with hospital admission. Regarding the vascular system, we found that having had thromboembolism before SARS-CoV-2 infection was significantly associated with a higher risk of recurrence of thromboembolism at 1 year. In the neurologic evaluation, the most frequent symptom was fatigue, which was observed in 87.5% of patients, followed by "feeling slowed down", headache, and smell disturbance in 71.5%, 68.5%, and 60.7% of cases, respectively. Finally, our cohort subjects scored higher overall in the STAI, CESD, Maastricht, and PSQI scores (which measure anxiety, depression, fatigue, and sleep, respectively) than the healthy population. Using cluster analysis, we identified two phenotypes of patients prone to developing Long COVID. At baseline, CCS score, prior chronic disease, stroke, and atrial fibrillation were associated with Long COVID. During COVID infection, mechanical ventilation and five neurological complaints were also associated with Long COVID. In conclusion, this study confirms the wide range of symptoms developed after COVID with the involvement of all the major systems. Early identification of risk factors associated with the development of Long COVID could improve patient follow-up; nevertheless, the low specificity of these factors remains a challenge to building a systematic approach.
Sujets
PID Serval
serval:BIB_D74F62B5F2C9
PMID
Open Access
Oui
Date de création
2023-04-17T11:10:52.118Z
Date de création dans IRIS
2025-05-21T00:29:22Z
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Nom
jcm-12-02673.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
983.98 KB
Format
Adobe PDF
PID Serval
serval:BIB_D74F62B5F2C9.P001
URN
urn:nbn:ch:serval-BIB_D74F62B5F2C95
Somme de contrôle
(MD5):f31282dd7453755a4976fb41945cab22