Titre
In silico validation of the Autoinflammatory Disease Damage Index.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Ter Haar, N.M.
Auteure/Auteur
van Delft, ALJ
Auteure/Auteur
Annink, K.V.
Auteure/Auteur
van Stel, H.
Auteure/Auteur
Al-Mayouf, S.M.
Auteure/Auteur
Amaryan, G.
Auteure/Auteur
Anton, J.
Auteure/Auteur
Barron, K.S.
Auteure/Auteur
Benseler, S.
Auteure/Auteur
Brogan, P.A.
Auteure/Auteur
Cantarini, L.
Auteure/Auteur
Cattalini, M.
Auteure/Auteur
Cochino, A.V.
Auteure/Auteur
de Benedetti, F.
Auteure/Auteur
Dedeoglu, F.
Auteure/Auteur
de Jesus, A.A.
Auteure/Auteur
Demirkaya, E.
Auteure/Auteur
Dolezalova, P.
Auteure/Auteur
Durrant, K.L.
Auteure/Auteur
Fabio, G.
Auteure/Auteur
Gallizzi, R.
Auteure/Auteur
Goldbach-Mansky, R.
Auteure/Auteur
Hachulla, E.
Auteure/Auteur
Hentgen, V.
Auteure/Auteur
Herlin, T.
Auteure/Auteur
Hofer, M.
Auteure/Auteur
Hoffman, H.M.
Auteure/Auteur
Insalaco, A.
Auteure/Auteur
Jansson, A.F.
Auteure/Auteur
Kallinich, T.
Auteure/Auteur
Kone-Paut, I.
Auteure/Auteur
Kozlova, A.
Auteure/Auteur
Kuemmerle-Deschner, J.B.
Auteure/Auteur
Lachmann, H.J.
Auteure/Auteur
Laxer, R.M.
Auteure/Auteur
Martini, A.
Auteure/Auteur
Nielsen, S.
Auteure/Auteur
Nikishina, I.
Auteure/Auteur
Ombrello, A.K.
Auteure/Auteur
Özen, S.
Auteure/Auteur
Papadopoulou-Alataki, E.
Auteure/Auteur
Quartier, P.
Auteure/Auteur
Rigante, D.
Auteure/Auteur
Russo, R.
Auteure/Auteur
Simon, A.
Auteure/Auteur
Trachana, M.
Auteure/Auteur
Uziel, Y.
Auteure/Auteur
Ravelli, A.
Auteure/Auteur
Schulert, G.
Auteure/Auteur
Gattorno, M.
Auteure/Auteur
Frenkel, J.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1468-2060
Statut éditorial
Publié
Date de publication
2018-11
Volume
77
Numéro
11
Première page
1599
Dernière page/numéro d’article
1605
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Autoinflammatory diseases can cause irreversible tissue damage due to systemic inflammation. Recently, the Autoinflammatory Disease Damage Index (ADDI) was developed. The ADDI is the first instrument to quantify damage in familial Mediterranean fever, cryopyrin-associated periodic syndromes, mevalonate kinase deficiency and tumour necrosis factor receptor-associated periodic syndrome. The aim of this study was to validate this tool for its intended use in a clinical/research setting.
The ADDI was scored on paper clinical cases by at least three physicians per case, independently of each other. Face and content validity were assessed by requesting comments on the ADDI. Reliability was tested by calculating the intraclass correlation coefficient (ICC) using an 'observer-nested-within-subject' design. Construct validity was determined by correlating the ADDI score to the Physician Global Assessment (PGA) of damage and disease activity. Redundancy of individual items was determined with Cronbach's alpha.
The ADDI was validated on a total of 110 paper clinical cases by 37 experts in autoinflammatory diseases. This yielded an ICC of 0.84 (95% CI 0.78 to 0.89). The ADDI score correlated strongly with PGA-damage (r=0.92, 95% CI 0.88 to 0.95) and was not strongly influenced by disease activity (r=0.395, 95% CI 0.21 to 0.55). After comments from disease experts, some item definitions were refined. The interitem correlation in all different categories was lower than 0.7, indicating that there was no redundancy between individual damage items.
The ADDI is a reliable and valid instrument to quantify damage in individual patients and can be used to compare disease outcomes in clinical studies.
The ADDI was scored on paper clinical cases by at least three physicians per case, independently of each other. Face and content validity were assessed by requesting comments on the ADDI. Reliability was tested by calculating the intraclass correlation coefficient (ICC) using an 'observer-nested-within-subject' design. Construct validity was determined by correlating the ADDI score to the Physician Global Assessment (PGA) of damage and disease activity. Redundancy of individual items was determined with Cronbach's alpha.
The ADDI was validated on a total of 110 paper clinical cases by 37 experts in autoinflammatory diseases. This yielded an ICC of 0.84 (95% CI 0.78 to 0.89). The ADDI score correlated strongly with PGA-damage (r=0.92, 95% CI 0.88 to 0.95) and was not strongly influenced by disease activity (r=0.395, 95% CI 0.21 to 0.55). After comments from disease experts, some item definitions were refined. The interitem correlation in all different categories was lower than 0.7, indicating that there was no redundancy between individual damage items.
The ADDI is a reliable and valid instrument to quantify damage in individual patients and can be used to compare disease outcomes in clinical studies.
PID Serval
serval:BIB_2962AA9B1BC8
PMID
Date de création
2018-08-13T12:22:06.178Z
Date de création dans IRIS
2025-05-20T14:55:46Z
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30077992_BIB_2962AA9B1BC8.pdf
Version du manuscrit
postprint
Licence
https://creativecommons.org/licenses/by/4.0
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259.26 KB
Format
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PID Serval
serval:BIB_2962AA9B1BC8.P001
URN
urn:nbn:ch:serval-BIB_2962AA9B1BC89
Somme de contrôle
(MD5):86b0fe1af599344d483e7dda97452ee6