Titre
Spatial structure, chemotaxis and quorum sensing shape bacterial biomass accumulation in complex porous media.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Scheidweiler, D.
Auteure/Auteur
Bordoloi, A.D.
Auteure/Auteur
Jiao, W.
Auteure/Auteur
Sentchilo, V.
Auteure/Auteur
Bollani, M.
Auteure/Auteur
Chhun, A.
Auteure/Auteur
Engel, P.
Auteure/Auteur
de Anna, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2041-1723
Statut éditorial
Publié
Date de publication
2024-01-02
Volume
15
Numéro
1
Première page
191
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Biological tissues, sediments, or engineered systems are spatially structured media with a tortuous and porous structure that host the flow of fluids. Such complex environments can influence the spatial and temporal colonization patterns of bacteria by controlling the transport of individual bacterial cells, the availability of resources, and the distribution of chemical signals for communication. Yet, due to the multi-scale structure of these complex systems, it is hard to assess how different biotic and abiotic properties work together to control the accumulation of bacterial biomass. Here, we explore how flow-mediated interactions allow the gut commensal Escherichia coli to colonize a porous structure that is composed of heterogenous dead-end pores (DEPs) and connecting percolating channels, i.e. transmitting pores (TPs), mimicking the structured surface of mammalian guts. We find that in presence of flow, gradients of the quorum sensing (QS) signaling molecule autoinducer-2 (AI-2) promote E. coli chemotactic accumulation in the DEPs. In this crowded environment, the combination of growth and cell-to-cell collision favors the development of suspended bacterial aggregates. This results in hot-spots of resource consumption, which, upon resource limitation, triggers the mechanical evasion of biomass from nutrients and oxygen depleted DEPs. Our findings demonstrate that microscale medium structure and complex flow coupled with bacterial quorum sensing and chemotaxis control the heterogenous accumulation of bacterial biomass in a spatially structured environment, such as villi and crypts in the gut or in tortuous pores within soil and filters.
PID Serval
serval:BIB_C15F89398E71
PMID
Open Access
Oui
Date de création
2024-01-10T13:19:45.228Z
Date de création dans IRIS
2025-05-21T03:57:55Z
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Nom
s41467-023-44267-y.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
9.25 MB
Format
Adobe PDF
PID Serval
serval:BIB_C15F89398E71.P001
URN
urn:nbn:ch:serval-BIB_C15F89398E717
Somme de contrôle
(MD5):8749fc3bad0e379d659cd846178eaa00