Titre
Connecting the dots: key insights on ParB for chromosome segregation from single-molecule studies.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Tišma, M.
Auteure/Auteur
Kaljević, J.
Auteure/Auteur
Gruber, S.
Auteure/Auteur
Le, TBK
Auteure/Auteur
Dekker, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1574-6976
Statut éditorial
Publié
Date de publication
2024-01-12
Volume
48
Numéro
1
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Review ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Bacterial cells require DNA segregation machinery to properly distribute a genome to both daughter cells upon division. The most common system involved in chromosome and plasmid segregation in bacteria is the ParABS system. A core protein of this system - partition protein B (ParB) - regulates chromosome organization and chromosome segregation during the bacterial cell cycle. Over the past decades, research has greatly advanced our knowledge of the ParABS system. However, many intricate details of the mechanism of ParB proteins were only recently uncovered using in vitro single-molecule techniques. These approaches allowed the exploration of ParB proteins in precisely controlled environments, free from the complexities of the cellular milieu. This review covers the early developments of this field but emphasizes recent advances in our knowledge of the mechanistic understanding of ParB proteins as revealed by in vitro single-molecule methods. Furthermore, we provide an outlook on future endeavors in investigating ParB, ParB-like proteins, and their interaction partners.
PID Serval
serval:BIB_5237C9726795
PMID
Open Access
Oui
Date de création
2024-01-10T09:40:31.055Z
Date de création dans IRIS
2025-05-20T19:56:01Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
38142222_BIB_5237C9726795.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
1.78 MB
Format
Adobe PDF
PID Serval
serval:BIB_5237C9726795.P001
URN
urn:nbn:ch:serval-BIB_5237C97267950
Somme de contrôle
(MD5):91f8d030fec47ac594dadb9270f71b44