Titre
Role of dietary carbohydrates and macronutrients in the pathogenesis of nonalcoholic fatty liver disease.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Lê, K.A.
Auteure/Auteur
Bortolotti, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1363-1950
Statut éditorial
Publié
Date de publication
2008
Volume
11
Numéro
4
Première page
477
Dernière page/numéro d’article
482
Peer-reviewed
Oui
Langue
anglais
Résumé
PURPOSE OF REVIEW: The prevalence of nonalcoholic fatty liver disease is increasing worldwide and there is strong evidence that dietary factors play a role in its pathogenesis. The present review aims to provide a better understanding of how carbohydrates and other macronutrients may affect the disease. RECENT FINDINGS: The effects of carbohydrates on the development of nonalcoholic fatty liver disease differ depending upon the carbohydrate type; high-glycemic index foods are related to increased hepatic fat in both rodents and humans. Similarly, simple carbohydrates, such as fructose, stimulate hepatic de-novo lipogenesis and decrease lipid oxidation, thus leading to increased fat deposition. The underlying mechanisms may involve the activation of transcription factors. Fat intake broadly leads to hepatic fat deposition in rodents but few data are available on humans. Both carbohydrates and fat trigger inflammatory factors, which are closely related to metabolic disorders and nonalcoholic fatty liver disease. Lifestyle interventions appear to be the most appropriate first-line treatment for nonalcoholic fatty liver disease. SUMMARY: There is strong evidence that the diet may affect the development of nonalcoholic fatty liver disease. Although simple carbohydrates are clearly shown to have deleterious effects in humans, the role of fat remains controversial. Further studies will be required to evaluate the effects of macronutrient composition on the development of nonalcoholic fatty liver disease.
PID Serval
serval:BIB_58EAA9C86960
PMID
Date de création
2009-01-29T21:12:56.293Z
Date de création dans IRIS
2025-05-20T16:11:09Z