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  4. Kingella kingae and Osteoarticular Infections.
 
  • Détails
Titre

Kingella kingae and Osteoarticular Infections.

Type
article
Institution
Externe
Périodique
Pediatrics  
Auteur(s)
Samara, E.
Auteure/Auteur
Spyropoulou, V.
Auteure/Auteur
Tabard-Fougère, A.
Auteure/Auteur
Merlini, L.
Auteure/Auteur
Valaikaite, R.
Auteure/Auteur
Dhouib, A.
Auteure/Auteur
Manzano, S.
Auteure/Auteur
Juchler, C.
Auteure/Auteur
Dayer, R.
Auteure/Auteur
Ceroni, D.
Auteure/Auteur
Liens vers les personnes
Samara, Eleftheria  
ISSN
1098-4275
Statut éditorial
Publié
Date de publication
2019-12
Volume
144
Numéro
6
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
In this study, we aimed to contrast the bacteriologic epidemiology of osteoarticular infections (OAIs) between 2 patient groups in successive 10-year periods, before and after the extensive use of nucleic acid amplification assays in the diagnostic process.
Epidemiologic data and bacteriologic etiologies of all children presenting with OAIs on admission to our institution over 20 years (1997-2016) were assessed retrospectively. The population was divided into 2 cohorts, using the standardized use of polymerase chain reaction as the cutoff point (2007). The conventional cohort included children with OAIs mainly investigated by using classic cultures, whereas the molecular cohort referred to patients also investigated by using molecular assays.
Kingella kingae was the most frequently isolated pathogen, responsible for 51% of OAIs, whereas other classic pathogens were responsible for 39.7% of cases in the molecular cohort. A statistically significant increase in the mean incidence of OAIs was observed, as was a decrease in the mean age at diagnosis after 2007. After 2007, the pathogen remained unidentified in 21.6% of OAIs in our pediatric population.
Extensive use of nucleic acid amplification assays improved the detection of fastidious pathogens and has increased the observed incidence of OAI, especially in children aged between 6 and 48 months. We propose the incorporation of polymerase chain reaction assays into modern diagnostic algorithms for OAIs to better identify the bacteriologic etiology of OAIs.
Sujets

Adolescent

Arthritis, Infectious...

Arthritis, Infectious...

Child

Child, Preschool

Cohort Studies

Female

Humans

Infant

Infant, Newborn

Kingella kingae/genet...

Kingella kingae/isola...

Male

Neisseriaceae Infecti...

Neisseriaceae Infecti...

Osteoarthritis/diagno...

Osteoarthritis/geneti...

Osteomyelitis/diagnos...

Osteomyelitis/genetic...

Real-Time Polymerase ...

Retrospective Studies...

PID Serval
serval:BIB_D6FCE8E9BE0C
DOI
10.1542/peds.2019-1509
PMID
31722963
WOS
000503171700024
Permalien
https://iris.unil.ch/handle/iris/230100
Open Access
Oui
Date de création
2021-07-23T09:52:20.536Z
Date de création dans IRIS
2025-05-21T05:04:34Z
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