Titre

Mobilizable genomic islands, different strategies for the dissemination of multidrug resistance and other adaptive traits.

Type
lettre à l'éditeur
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Mobile Genetic Elements
Auteur(s)
Carraro, N.
Auteure/Auteur
Rivard, N.
Auteure/Auteur
Burrus, V.
Auteure/Auteur
Ceccarelli, D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2159-2543
Statut éditorial
Publié
Date de publication
2017
Volume
7
Numéro
2
Première page
1
Dernière page/numéro d’article
6
Peer-reviewed
Oui
Langue
anglais
Résumé
Mobile genetic elements are near ubiquitous DNA segments that revealed a surprising variety of strategies for their propagation among prokaryotes and between eukaryotes. In bacteria, conjugative elements were shown to be key drivers of evolution and adaptation by efficiently disseminating genes involved in pathogenicity, symbiosis, metabolic pathways, and antibiotic resistance. Conjugative plasmids of the incompatibility groups A and C (A/C) are important vehicles for the dissemination of antibiotic resistance and the consequent global emergence and spread of multi-resistant pathogenic bacteria. Beyond their own mobility, A/C plasmids were also shown to drive the mobility of unrelated non-autonomous mobilizable genomic islands, which may also confer further advantageous traits. In this commentary, we summarize the current knowledge on different classes of A/C-dependent mobilizable genomic islands and we discuss other DNA hitchhikers and their implication in bacterial evolution. Furthermore, we glimpse at the complex genetic network linking autonomous and non-autonomous mobile genetic elements, and at the associated flow of genetic information between bacteria.
PID Serval
serval:BIB_5A28AD4C9121
DOI
PMID
Permalien
Date de création
2017-04-29T14:44:23.304Z
Date de création dans IRIS
2025-05-20T20:21:35Z
Fichier(s)
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Vignette d'image
Nom

28439449_BIB_5A28AD4C9121.pdf

Version du manuscrit

published

Taille

540.63 KB

Format

Adobe PDF

PID Serval

serval:BIB_5A28AD4C9121.P001

URN

urn:nbn:ch:serval-BIB_5A28AD4C91216

Somme de contrôle

(MD5):9dd45f0d92fbb28e005f0c065b26b934