Titre
Ultrawidefield indocyanine green angiographic changes after photodynamic therapy in central serous chorioretinopathy: certain study report 3.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Pauleikhoff, LJB
Auteure/Auteur
Chang-Wolf, J.M.
Auteure/Auteur
Diederen, RMH
Auteure/Auteur
Moll, A.C.
Auteure/Auteur
Schlingemann, R.O.
Auteure/Auteur
van Dijk, EHC
Auteure/Auteur
Boon, CJF
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1539-2864
Statut éditorial
Publié
Date de publication
2025-06-01
Volume
45
Numéro
6
Première page
1143
Dernière page/numéro d’article
1150
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Venous overload choroidopathy, showing pachyvessels, choroidal intervortex venous anastomoses, asymmetric venous drainage, choroidal vascular hyperpermeability (CVH), and increased choroidal thickness, is observed in most patients with central serous chorioretinopathy based on ultrawidefield indocyanine green angiography. This report investigates how photodynamic therapy alters signs of venous overload choroidopathy.
The CERTAIN study is a monocentric, retrospective study on consecutive central serous chorioretinopathy patients who underwent ultrawidefield indocyanine green angiography. For this report, patients who underwent ultrawidefield indocyanine green angiography twice were included. Two independent graders assessed changes in pachyvessels, choroidal intervortex venous anastomoses, AVD, choroidal thickness, and CVH when comparing pre-photodynamic and post-photodynamic therapy images of treated and untreated eyes.
In total, 38 eyes (19 patients) were included. Of those, 19 eyes had undergone photodynamic therapy, and 19 had not. Photodynamic therapy had no significant effect on pachyvessels, choroidal intervortex venous anastomoses, and asymmetric venous drainage (all P > 0.05). Only choroidal thickness (-51 ± 48 vs. 1 ± 43 µ m, P = 0.006) and CVH within the photodynamic therapy treatment area (79% vs. 0% reduced CVH, P < 0.0001) were significantly decreased in treated versus untreated eyes.
Photodynamic therapy reduced choroidal thickness and CVH within the treatment area while not significantly altering the overall choroidal vascular architecture associated with venous overload choroidopathy.
The CERTAIN study is a monocentric, retrospective study on consecutive central serous chorioretinopathy patients who underwent ultrawidefield indocyanine green angiography. For this report, patients who underwent ultrawidefield indocyanine green angiography twice were included. Two independent graders assessed changes in pachyvessels, choroidal intervortex venous anastomoses, AVD, choroidal thickness, and CVH when comparing pre-photodynamic and post-photodynamic therapy images of treated and untreated eyes.
In total, 38 eyes (19 patients) were included. Of those, 19 eyes had undergone photodynamic therapy, and 19 had not. Photodynamic therapy had no significant effect on pachyvessels, choroidal intervortex venous anastomoses, and asymmetric venous drainage (all P > 0.05). Only choroidal thickness (-51 ± 48 vs. 1 ± 43 µ m, P = 0.006) and CVH within the photodynamic therapy treatment area (79% vs. 0% reduced CVH, P < 0.0001) were significantly decreased in treated versus untreated eyes.
Photodynamic therapy reduced choroidal thickness and CVH within the treatment area while not significantly altering the overall choroidal vascular architecture associated with venous overload choroidopathy.
Sujets
PID Serval
serval:BIB_FC6D39F01E8D
PMID
Open Access
Oui
Date de création
2025-02-17T16:08:01.636Z
Date de création dans IRIS
2025-07-12T04:18:31Z
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Nom
39913786.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
313.12 KB
Format
Adobe PDF
PID Serval
serval:BIB_FC6D39F01E8D.P001
URN
urn:nbn:ch:serval-BIB_FC6D39F01E8D3
Somme de contrôle
(MD5):d332fd055cebf6636712fbce481a4b75