Titre
Blood coagulation in postmenopausal women given estrogen treatment: comparison of transdermal and oral administration
Type
article
Institution
Externe
Périodique
Journal of Laboratory and Clinical Medicine
Auteur(s)
Alkjaersig, N.
Auteure/Auteur
Fletcher, A. P.
Auteure/Auteur
de Ziegler, D.
Auteure/Auteur
Steingold, K. A.
Auteure/Auteur
Meldrum, D. R.
Auteure/Auteur
Judd, H. L.
Auteure/Auteur
Liens vers les personnes
ISSN
0022-2143
Statut éditorial
Publié
Date de publication
1988-02
Volume
111
Numéro
2
Première page
224
Dernière page/numéro d’article
8
Peer-reviewed
Oui
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Feb
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Feb
Résumé
The responses of the blood coagulation and related systems were studied in 23 postmenopausal women, all of whom received, in randomized order, therapy with conjugated oral estrogens (0.625 and 1.25 mg daily) and transdermally administered estradiol in doses of 25, 50, 100, and 200 micrograms/24 hr. Neither plasma fibrinopeptide A determinations nor plasma fibrinogen chromatographic findings were altered; thus there is no evidence of accelerated fibrinogen turnover with either form of therapy. However, alpha 1-antitrypsin and plasminogen concentrations were significantly increased with the higher dosage of oral but not with transdermally administered estrogen. Similarly, ceruloplasmin concentration was significantly elevated with both oral doses but was unchanged by transdermal therapy.
Sujets
PID Serval
serval:BIB_98350248F4B3
PMID
Date de création
2008-02-28T10:36:53.289Z
Date de création dans IRIS
2025-05-21T03:17:40Z