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  4. Invasive Mold Infections in Allogeneic Hematopoietic Cell Transplant Recipients in 2020: Have We Made Enough Progress?
 
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Titre

Invasive Mold Infections in Allogeneic Hematopoietic Cell Transplant Recipients in 2020: Have We Made Enough Progress?

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Open Forum Infectious Diseases  
Auteur(s)
Roth, R.S.
Auteure/Auteur
Masouridi-Levrat, S.
Auteure/Auteur
Chalandon, Y.
Auteure/Auteur
Mamez, A.C.
Auteure/Auteur
Giannotti, F.
Auteure/Auteur
Riat, A.
Auteure/Auteur
Fischer, A.
Auteure/Auteur
Poncet, A.
Auteure/Auteur
Glampedakis, E.
Auteure/Auteur
Van Delden, C.
Auteure/Auteur
Kaiser, L.
Auteure/Auteur
Neofytos, D.
Auteure/Auteur
Liens vers les personnes
Glampedakis, Emmanouil  
Liens vers les unités
Maladies infectieuses  
ISSN
2328-8957
Statut éditorial
Publié
Date de publication
2022-01
Volume
9
Numéro
1
Première page
ofab596
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Despite progress in diagnostic, prevention, and treatment strategies, invasive mold infections (IMIs) remain the leading cause of mortality in allogeneic hematopoietic cell transplant (allo-HCT) recipients.
We describe the incidence, risk factors, and mortality of allo-HCT recipients with proven/probable IMI in a retrospective single-center 10-year (01/01/2010-01/01/2020) cohort study.
Among 515 allo-HCT recipients, 48 (9.3%) patients developed 51 proven/probable IMI: invasive aspergillosis (IA; 34/51, 67%), mucormycosis (9/51, 18%), and other molds (8/51, 15%). Overall, 35/51 (68.6%) breakthrough IMIs (bIMIs) were identified: 22/35 (62.8%) IA and 13/35 (37.1%) non-IA IMI. One-year IMI cumulative incidence was 7%: 4.9% and 2.1% for IA and non-IA IMI, respectively. Fourteen (29.2 %), 10 (20.8%), and 24 (50.0%) patients were diagnosed during the first 30, 31-180, and >180 days post-HCT, respectively. Risk factors for IMI included prior allo-HCT (sub hazard ratio [SHR], 4.06; P = .004) and grade ≥2 acute graft-vs-host disease (aGvHD; SHR, 3.52; P < .001). All-cause 1-year mortality was 33% (170/515): 48% (23/48) and 31.5% (147/467) for patients with and without IMI (P = .02). Mortality predictors included disease relapse (hazard ratio [HR], 7.47; P < .001), aGvHD (HR, 1.51; P = .001), CMV serology-positive recipients (HR, 1.47; P = .03), and IMI (HR, 3.94; P < .001). All-cause 12-week mortality for patients with IMI was 35.4% (17/48): 31.3% (10/32) for IA and 43.8% (7/16) for non-IA IMI (log-rank P = .47). At 1 year post-IMI diagnosis, 70.8% (34/48) of the patients were dead.
IA mortality has remained relatively unchanged during the last 2 decades. More than two-thirds of allo-HCT recipients with IMI die by 1 year post-IMI diagnosis. Dedicated intensified research efforts are required to further improve clinical outcomes.
Sujets

allogeneic hematopoie...

epidemiology

invasive aspergillosi...

invasive mold infecti...

mortality

PID Serval
serval:BIB_0B58708FBA7C
DOI
10.1093/ofid/ofab596
PMID
34993259
WOS
000744981900024
Permalien
https://iris.unil.ch/handle/iris/101612
Open Access
Oui
Date de création
2022-01-17T10:49:49.974Z
Date de création dans IRIS
2025-05-20T18:38:38Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

34993259_BIB_0B58708FBA7C.pdf

Version du manuscrit

published

Licence

https://creativecommons.org/licenses/by-nc-nd/4.0

Taille

301.34 KB

Format

Adobe PDF

PID Serval

serval:BIB_0B58708FBA7C.P001

URN

urn:nbn:ch:serval-BIB_0B58708FBA7C2

Somme de contrôle

(MD5):32775a66c7b7c2259ad8dfd7122c263f

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