Titre
HCMV Envelope Glycoprotein Diversity Demystified
Type
article
Institution
Externe
Périodique
Auteur(s)
Foglierini, M.
Auteure/Auteur
Marcandalli, J.
Auteure/Auteur
Perez, L.
Auteure/Auteur
Liens vers les personnes
ISSN
1664-302X
Statut éditorial
Publié
Date de publication
2019
Volume
10
Première page
1005
Langue
anglais
Notes
1664-302x
Foglierini, Mathilde
Marcandalli, Jessica
Perez, Laurent
Journal Article
Front Microbiol. 2019 May 15;10:1005. doi: 10.3389/fmicb.2019.01005. eCollection 2019.
Foglierini, Mathilde
Marcandalli, Jessica
Perez, Laurent
Journal Article
Front Microbiol. 2019 May 15;10:1005. doi: 10.3389/fmicb.2019.01005. eCollection 2019.
Résumé
Human cytomegalovirus (HCMV) is the leading viral cause of congenital birth defects and is responsible for morbidity and mortality in immunosuppressed individuals. Considerable efforts have been deployed over the last decade to develop a vaccine capable of preventing HCMV infection. However, in recent clinical trials, vaccines showed at best modest efficacy in preventing infection. These findings might be explained by the high level of sequence polymorphism at the genomic level. To investigate if genomic variation also leads to antigenic variation, we performed a bioinformatic sequence analysis and evaluated the percentage of conservation at the amino acid level of all the proteins present in the virion envelope. Using more than two hundred sequences per envelope glycoprotein and analyzing their degree of conservation, we observe that antigenic variation is in large part limited to three proteins. In addition, we demonstrate that the two leading vaccine candidates, the pentamer and gB complexes, are well conserved at the amino acid level. These results suggest that despite genomic polymorphism, antigenic variability is not involved in the modest efficacy observed in the recent clinical trials for a HCMV vaccine. We therefore propose that next-generation vaccines should focus on stabilizing and refining the gB domains needed to induce a protective humoral response.
PID Serval
serval:BIB_4104AA3DF94F
Date de création
2020-09-04T18:03:35.870Z
Date de création dans IRIS
2025-05-20T18:02:46Z