Titre
Negative regulation of cell-cycle progression by RINGO/Speedy E
Type
article
Institution
Externe
Périodique
Auteur(s)
Dinarina, A.
Auteure/Auteur
Ruiz, E. J.
Auteure/Auteur
O'Loghlen, A.
Auteure/Auteur
Mouron, S.
Auteure/Auteur
Perez, L.
Auteure/Auteur
Nebreda, A. R.
Auteure/Auteur
Liens vers les personnes
ISSN
0264-6021
Statut éditorial
Publié
Date de publication
2008
Volume
410
Numéro
3
Première page
535
Dernière page/numéro d’article
42
Langue
anglais
Notes
1470-8728
Dinarina, Ana
Ruiz, E Josué
O'Loghlen, Ana
Mouron, Silvana
Perez, Laurent
Nebreda, Angel R
Journal Article
Research Support, Non-U.S. Gov't
England
Biochem J. 2008 Mar 15;410(3):535-42. doi: 10.1042/BJ20071453.
Dinarina, Ana
Ruiz, E Josué
O'Loghlen, Ana
Mouron, Silvana
Perez, Laurent
Nebreda, Angel R
Journal Article
Research Support, Non-U.S. Gov't
England
Biochem J. 2008 Mar 15;410(3):535-42. doi: 10.1042/BJ20071453.
Résumé
Cell-cycle transitions are controlled by CDKs (cyclin-dependent kinases), whose activation is usually associated with the binding of cyclins. RINGO/Speedy proteins can also bind to and activate CDKs, although they do not have amino acid sequence homology with cyclins. The RINGO/Speedy family members studied so far positively regulate cell-cycle progression. In the present paper, we report the biochemical and functional characterization of RINGO/Speedy E. We show that RINGO/Speedy E is a functionally distant member of this protein family that negatively affects cell-cycle progression. RINGO/Speedy E overexpression inhibits the meiotic progression in Xenopus oocytes as well as the proliferation of mammalian cells. RINGO/Speedy E can bind to endogenous CDK1 and CDK2 in both cellular systems. However, the RINGO/Speedy E-activated CDKs have different substrate specificity than the CDKs activated by other RINGO/Speedy proteins, which may account for their different effects on the cell cycle. Our results indicate that, although all RINGO/Speedy family members can activate CDKs, they may differently regulate cell-cycle progression.
PID Serval
serval:BIB_791D7789F41C
Date de création
2020-09-04T18:03:36.126Z
Date de création dans IRIS
2025-05-21T03:14:15Z