Titre
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.
Type
article
Institution
Externe
Auteur(s)
Jacob, C.O.
Auteure/Auteur
Aiso, S.
Auteure/Auteur
Michie, S.A.
Auteure/Auteur
McDevitt, H.O.
Auteure/Auteur
Acha-Orbea, H.
Auteure/Auteur
Liens vers les personnes
ISSN
0027-8424
Statut éditorial
Publié
Date de publication
1990
Volume
87
Numéro
3
Première page
968
Dernière page/numéro d’article
972
Langue
anglais
Résumé
The role of tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of autoimmune diabetes mellitus was tested in the nonobese mouse (NOD) model system. The effects of TNF-alpha were assessed on three levels: (i) insulitis development, (ii) development of overt diabetes, (iii) adoptive transfer of diabetes by splenic lymphocytes. Spontaneous diabetes mellitus was blocked in NOD mice by long-term treatment with recombinant TNF-alpha. Treatment with TNF-alpha caused a significant reduction in the lymphocytic infiltration associated with the destruction of the insulin-producing beta cells. Class II major histocompatibility complex Ia expression by islet cells was not up-regulated by TNF-alpha. Moreover, TNF-alpha was able to suppress the induction of diabetes in adoptive transfer of lymphocytes from diabetic female mice to young nondiabetic male NOD mice. These activities of TNF-alpha were shared by interleukin 1 alpha in this system. These studies have implications for the pathogenesis and therapy of autoimmune diabetes mellitus.
Sujets
PID Serval
serval:BIB_E7E1A402725C
PMID
Open Access
Oui
Date de création
2008-01-24T13:48:28.803Z
Date de création dans IRIS
2025-05-21T06:11:00Z