Titre
Heart rate variability and peripheral nerve conduction velocity in relation to blood lead in newly hired lead workers.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Yu, C.G.
Auteure/Auteur
Wei, F.F.
Auteure/Auteur
Yang, W.Y.
Auteure/Auteur
Zhang, Z.Y.
Auteure/Auteur
Mujaj, B.
Auteure/Auteur
Thijs, L.
Auteure/Auteur
Feng, Y.M.
Auteure/Auteur
Staessen, J.A.
Auteure/Auteur
Liens vers les unités
ISSN
1470-7926
Statut éditorial
Publié
Date de publication
2019-06
Volume
76
Numéro
6
Première page
382
Dernière page/numéro d’article
388
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Previous studies relating nervous activity to blood lead (BL) levels have limited relevance, because over time environmental and occupational exposure substantially dropped. We investigated the association of heart rate variability (HRV) and median nerve conduction velocity (NCV) with BL using the baseline measurements collected in the Study for Promotion of Health in Recycling Lead (NCT02243904).
In 328 newly hired men (mean age 28.3 years; participation rate 82.7%), we derived HRV measures (power expressed in normalised units (nu) in the high-frequency (HF) and low-frequency (LF) domains, and LF/HF) prior to long-term occupational lead exposure. Five-minute ECG recordings, obtained in the supine and standing positions, were analysed by Fourier transform or autoregressive modelling, using Cardiax software. Motor NCV was measured at the median nerve by a handheld device (Brevio Nerve Conduction Monitoring System, NeuMed, West Trenton, NJ, USA). BL was determined by inductively coupled plasma mass spectrometry.
Mean BL was 4.54 µg/dL (IQR 2.60-8.90 µg/dL). Mean supine and standing values of LF, HF and LF/HF were 50.5 and 21.1 nu and 2.63, and 59.7 and 10.9 nu and 6.31, respectively. Orthostatic stress decreased HF and increased LF (p<0.001). NCV averaged 3.74 m/s. Analyses across thirds of the BL distribution and multivariable-adjusted regression analyses failed to demonstrate any association of HRV or NCV with BL.
At the exposure levels observed in our study, autonomous nervous activity and NCV were not associated with BL.
NCT02243904.
In 328 newly hired men (mean age 28.3 years; participation rate 82.7%), we derived HRV measures (power expressed in normalised units (nu) in the high-frequency (HF) and low-frequency (LF) domains, and LF/HF) prior to long-term occupational lead exposure. Five-minute ECG recordings, obtained in the supine and standing positions, were analysed by Fourier transform or autoregressive modelling, using Cardiax software. Motor NCV was measured at the median nerve by a handheld device (Brevio Nerve Conduction Monitoring System, NeuMed, West Trenton, NJ, USA). BL was determined by inductively coupled plasma mass spectrometry.
Mean BL was 4.54 µg/dL (IQR 2.60-8.90 µg/dL). Mean supine and standing values of LF, HF and LF/HF were 50.5 and 21.1 nu and 2.63, and 59.7 and 10.9 nu and 6.31, respectively. Orthostatic stress decreased HF and increased LF (p<0.001). NCV averaged 3.74 m/s. Analyses across thirds of the BL distribution and multivariable-adjusted regression analyses failed to demonstrate any association of HRV or NCV with BL.
At the exposure levels observed in our study, autonomous nervous activity and NCV were not associated with BL.
NCT02243904.
PID Serval
serval:BIB_9D3353C7F5F2
PMID
Open Access
Oui
Date de création
2019-04-15T07:53:49.775Z
Date de création dans IRIS
2025-05-21T01:45:46Z
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Nom
BIB_9D3353C7F5F2.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
429.91 KB
Format
Adobe PDF
PID Serval
serval:BIB_9D3353C7F5F2.P001
URN
urn:nbn:ch:serval-BIB_9D3353C7F5F28
Somme de contrôle
(MD5):42708c3b071921c6d75772db49da5b9f