Titre
International experience with conversion from cyclosporine to tacrolimus for acute and chronic lung allograft rejection.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Sarahrudi, K.
Auteure/Auteur
Estenne, M.
Auteure/Auteur
Corris, P.
Auteure/Auteur
Niedermayer, J.
Auteure/Auteur
Knoop, C.
Auteure/Auteur
Glanville, A.
Auteure/Auteur
Chaparro, C.
Auteure/Auteur
Verleden, G.
Auteure/Auteur
Gerbase, M.W.
Auteure/Auteur
Venuta, F.
Auteure/Auteur
Böttcher, H.
Auteure/Auteur
Aubert, J.D.
Auteure/Auteur
Levvey, B.
Auteure/Auteur
Reichenspurner, H.
Auteure/Auteur
Auterith, A.
Auteure/Auteur
Klepetko, W.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0022-5223
Statut éditorial
Publié
Date de publication
2004
Volume
127
Numéro
4
Première page
1126
Dernière page/numéro d’article
1132
Peer-reviewed
Oui
Langue
anglais
Résumé
OBJECTIVE: A retrospective study involving 13 institutions was performed to assess the efficacy of conversion from cyclosporine (INN: ciclosporin) to tacrolimus. METHODS: Data from 244 patients were analyzed. Indications for conversion were recurrent-ongoing rejection (n = 110) and stage 1 to 3 bronchiolitis obliterans syndrome (n = 134). RESULTS: The incidence of acute rejection decreased significantly within 3 months after versus before the switch from cyclosporine to tacrolimus (P <.01). For patients with recurrent-ongoing rejection, the forced expiratory volume in 1 second decreased by 1.96% of predicted value per month (P =.08 vs zero slope) before and increased by 0.34% of predicted value per month (P =.32 vs zero slope) after conversion (P <.06). For patients with stage 1 to 3 bronchiolitis obliterans syndrome, a significant reduction of rejection episodes was observed (P <.01). In single transplant recipients a decrease of the forced expiratory volume in 1 second averaged 2.25% of predicted value per month (P <.01 vs zero slope) before and 0.29% of predicted value per month after conversion. Corresponding values for bilateral transplant recipients were 3.7% of predicted value per month (P <.01 vs zero slope) and 0.9% of predicted value per month (P = 0.04 vs zero slope), respectively. No significant difference in the incidence of infections within 3 months before and after conversion was observed. CONCLUSIONS: Conversion from cyclosporine to tacrolimus after lung transplantation is associated with reversal of recurrent-ongoing rejection. Conversion for bronchiolitis obliterans syndrome allows short-term stabilization of lung function in most patients.
Sujets
PID Serval
serval:BIB_43AD7D98D4B6
PMID
Open Access
Oui
Date de création
2008-01-21T11:54:14.114Z
Date de création dans IRIS
2025-05-20T18:50:25Z