Titre
Site of the action of a synthetic atrial natriuretic peptide evaluated in humans.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Biollaz, J.
Auteure/Auteur
Bidiville, J.
Auteure/Auteur
Diézi, J.
Auteure/Auteur
Waeber, B.
Auteure/Auteur
Nussberger, J.
Auteure/Auteur
Brunner-Ferber, F.
Auteure/Auteur
Gomez, H.J.
Auteure/Auteur
Brunner, H.R.
Auteure/Auteur
Liens vers les personnes
ISSN
0085-2538
Statut éditorial
Publié
Date de publication
1987
Volume
32
Numéro
4
Première page
537
Dernière page/numéro d’article
546
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The renal site of the natriuretic effect of human, atrial natriuretic peptide (hANP) was studied using clearance techniques in eight salt-loaded normal volunteers undergoing maximal water diuresis. Lithium was used as a marker of proximal sodium reabsorption. According to a two-way, single blind, crossover design, hANP (Met12-(3-28)-eicosahexapeptide, (2 micrograms/min) or its vehicle (Ve) were infused for two hours, followed by a two-hour recovery period. Blood pressure, heart rate and insulin clearance remained unchanged. During hANP infusion, the filtration fraction increased slightly from 19.6 to 24.3% (P less than 0.001), fractional water excretion rose transiently at the beginning of the infusion. Fractional excretion of sodium increased markedly from 2.2% to 7.4% (P less than 0.001) but remained unchanged with Ve. ANP increased fractional excretion of lithium slightly from 46 to 58% (P less than 0.01), while it remained stable at 47% during Ve. The distal tubular rejection fraction of sodium calculated from sodium and lithium clearances rose markedly from 4.7 to 13% (P less than 0.001) and returned to 6.2% at the end of the recovery period. Thus, under salt loading and water diuresis conditions, hANP infusion did not alter GFR, but reduced proximal reabsorption of sodium, and markedly enhanced the fraction of sodium escaping distal tubular reabsorption, suggesting that hANP-induced natriuresis is due, for an important part, to inhibition of sodium reabsorption in the distal nephron.
Sujets
PID Serval
serval:BIB_B65D518F86EC
PMID
Open Access
Oui
Date de création
2008-01-21T10:54:46.987Z
Date de création dans IRIS
2025-05-21T01:51:08Z