Titre
Social phobia is associated with suicide attempt history in bipolar inpatients
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Perroud, Nader
Auteure/Auteur
Baud, Patrick
Auteure/Auteur
Preisig, Martin
Auteure/Auteur
Etain, Bruno
Auteure/Auteur
Bellivier, Frank
Auteure/Auteur
Favre, Sophie
Auteure/Auteur
Reber, Nadja
Auteure/Auteur
Ferrero, François
Auteure/Auteur
Leboyer, Marion
Auteure/Auteur
Malafosse, Alain
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1398-5647
Statut éditorial
Publié
Date de publication
2007
Volume
9
Numéro
7
Première page
713
Dernière page/numéro d’article
721
Peer-reviewed
Oui
Langue
anglais
Notes
SAPHIRID:63942
Résumé
Objectives: In an attempt to reduce the phenotypical heterogeneity in an ongoing genetic study of suicidal behavior, we investigated the impact of comorbid anxiety disorders on suicidal behavior in bipolar disorder (BD) patients.
Methods: Anxiety disorders were compared in 406 BD I and BD II patients with or without lifetime history of suicide attempt.
Results: Among anxiety disorders, only social phobia (SP) was significantly associated with history of suicide attempt in BD [p < 0.001, odds ratio 4.26 (2.284-7.946)]. Moreover, onset of SP was found to precede onset of BD.
Conclusions: This result suggests that SP is an important risk factor for suicidal behavior in BD. Further studies are required to determine whether comorbid SP may help to identify a more homogeneous BD sub-group, especially when studies of suicidal behavior are conducted. A second question is whether SP identifies a sub-group of subjects with BD who have a more severe illness course and whether treatment of SP with selective serotonin reuptake inhibitor (SSRI) antidepressants is associated with improvement or worsening of the course of BD.
Methods: Anxiety disorders were compared in 406 BD I and BD II patients with or without lifetime history of suicide attempt.
Results: Among anxiety disorders, only social phobia (SP) was significantly associated with history of suicide attempt in BD [p < 0.001, odds ratio 4.26 (2.284-7.946)]. Moreover, onset of SP was found to precede onset of BD.
Conclusions: This result suggests that SP is an important risk factor for suicidal behavior in BD. Further studies are required to determine whether comorbid SP may help to identify a more homogeneous BD sub-group, especially when studies of suicidal behavior are conducted. A second question is whether SP identifies a sub-group of subjects with BD who have a more severe illness course and whether treatment of SP with selective serotonin reuptake inhibitor (SSRI) antidepressants is associated with improvement or worsening of the course of BD.
PID Serval
serval:BIB_ECF66E2B147A
Date de création
2008-03-13T07:39:39.551Z
Date de création dans IRIS
2025-05-20T22:59:09Z