Titre
Engraftment potential of human amnion and chorion cells derived from term placenta
Type
article
Institution
Externe
Périodique
Auteur(s)
Bailo, M.
Auteure/Auteur
Soncini, M.
Auteure/Auteur
Vertua, E.
Auteure/Auteur
Signoroni, P. B.
Auteure/Auteur
Sanzone, S.
Auteure/Auteur
Lombardi, G.
Auteure/Auteur
Arienti, D.
Auteure/Auteur
Calamani, F.
Auteure/Auteur
Zatti, D.
Auteure/Auteur
Paul, P.
Auteure/Auteur
Albertini, A.
Auteure/Auteur
Zorzi, F.
Auteure/Auteur
Cavagnini, A.
Auteure/Auteur
Candotti, F.
Auteure/Auteur
Wengler, G. S.
Auteure/Auteur
Parolini, O.
Auteure/Auteur
Liens vers les personnes
ISSN
0041-1337
Statut éditorial
Publié
Date de publication
2004
Volume
78
Numéro
10
Première page
1439
Dernière page/numéro d’article
48
Langue
anglais
Notes
Bailo, Marco
Soncini, Maddalena
Vertua, Elsa
Signoroni, Patrizia Bonassi
Sanzone, Silvia
Lombardi, Guerino
Arienti, Davide
Calamani, Francesca
Zatti, Daniela
Paul, Petra
Albertini, Alberto
Zorzi, Fausto
Cavagnini, Angelo
Candotti, Fabio
Wengler, Georg S
Parolini, Ornella
eng
Research Support, Non-U.S. Gov't
Transplantation. 2004 Nov 27;78(10):1439-48.
Soncini, Maddalena
Vertua, Elsa
Signoroni, Patrizia Bonassi
Sanzone, Silvia
Lombardi, Guerino
Arienti, Davide
Calamani, Francesca
Zatti, Daniela
Paul, Petra
Albertini, Alberto
Zorzi, Fausto
Cavagnini, Angelo
Candotti, Fabio
Wengler, Georg S
Parolini, Ornella
eng
Research Support, Non-U.S. Gov't
Transplantation. 2004 Nov 27;78(10):1439-48.
Résumé
BACKGROUND: Fetal membranes are tissues of particular interest for several reasons, including their role in preventing rejection of the fetus and their early embryologic origin. which may entail progenitor potential. The immunologic reactivity and the transplantation potential of amnion and chorion cells, however, remain to be elucidated. METHODS: Amnion and chorion cells were isolated from human term placenta and characterized by immunohistochemistry, flow cytometric analysis, and expression profile of relevant genes. The immunomodulatory characteristics of these cells were studied in allogeneic and xenogeneic mixed lymphocyte reactions and their engraftment potential analyzed by transplantation into neonatal swine and rats. Posttransplant chimerism was determined by polymerase chain reaction analysis with probes specific for human DNA. RESULTS: Phenotypic and gene expression studies indicated mesenchymal stem cell-like profiles in both amnion and chorion cells that were positive for neuronal, pulmonary, adhesion, and migration markers. In addition, cells isolated both from amnion and chorion did not induce allogeneic nor xenogeneic lymphocyte proliferation responses and were able to actively suppress lymphocyte responsiveness. Transplantation in neonatal swine and rats resulted in human microchimerism in various organs and tissues. CONCLUSIONS: Human amnion and chorion cells from term placenta can successfully engraft neonatal swine and rats. These results may be explained by the peculiar immunologic characteristics and mesenchymal stem cell-like phenotype of these cells. These findings suggest that amnion and chorion cells may represent an advantageous source of progenitor cells with potential applications in a variety of cell therapy and transplantation procedures.
PID Serval
serval:BIB_33B5817021F9
PMID
Date de création
2017-11-01T09:29:16.384Z
Date de création dans IRIS
2025-05-20T16:52:08Z