Titre
Neurobiology of cataplexy.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Seifinejad, A.
Auteure/Auteur
Vassalli, A.
Auteure/Auteur
Tafti, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1532-2955
Statut éditorial
Publié
Date de publication
2021-12
Volume
60
Première page
101546
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Cataplexy is the pathognomonic and the most striking symptom of narcolepsy. It has originally been, and still is now, widely considered as an abnormal manifestation of rapid eye movement (REM) sleep during wakefulness due to the typical muscle atonia. The neurocircuits of cataplexy, originally confined to the brainstem as those of REM sleep atonia, now include the hypothalamus, dorsal raphe (DR), amygdala and frontal cortex, and its neurochemistry originally focused on catecholamines and acetylcholine now extend to hypocretin (HCRT) and other neuromodulators. Here, we review the neuroanatomy and neurochemistry of cataplexy and propose that cataplexy is a distinct brain state that, despite similarities with REM sleep, involves cataplexy-specific features.
PID Serval
serval:BIB_C8F1AC8D7AC4
PMID
Date de création
2021-10-12T12:41:05.059Z
Date de création dans IRIS
2025-05-20T21:49:04Z
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Nom
1-s2.0-S1087079221001313-main.pdf
Version du manuscrit
published
Taille
1.54 MB
Format
Adobe PDF
PID Serval
serval:BIB_C8F1AC8D7AC4.P001
Somme de contrôle
(MD5):48cba5d37517ad61bf6b1da826fefe49