Titre

The effect of combined antiretroviral therapy on the overall mortality of HIV-infected individuals.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Ray, M.
Auteure/Auteur
Ray, M.
Auteure/Auteur
Logan, R.
Auteure/Auteur
Sterne, J.A.
Auteure/Auteur
Hernández-Díaz, S.
Auteure/Auteur
Robins, J.M.
Auteure/Auteur
Sabin, C.
Auteure/Auteur
Bansi, L.
Auteure/Auteur
van Sighem, A.
Auteure/Auteur
de Wolf, F.
Auteure/Auteur
Costagliola, D.
Auteure/Auteur
Lanoy, E.
Auteure/Auteur
Bucher, H.C.
Auteure/Auteur
von Wyl, V.
Auteure/Auteur
Esteve, A.
Auteure/Auteur
Casbona, J.
Auteure/Auteur
del Amo, J.
Auteure/Auteur
Moreno, S.
Auteure/Auteur
Justice, A.
Auteure/Auteur
Goulet, J.
Auteure/Auteur
Lodi, S.
Auteure/Auteur
Phillips, A.
Auteure/Auteur
Seng, R.
Auteure/Auteur
Meyer, L.
Auteure/Auteur
Pérez-Hoyos, S.
Auteure/Auteur
García de Olalla, P.
Auteure/Auteur
Hernán, M.A.
Auteure/Auteur
Contributrices/contributeurs
Phillips, AN.
Gilson, R.
Easterbrook, P.
Fisher, M.
Gazzard, B.
Johnson, M.
Walsh, J.
Leen, C.
Orkin, C.
Anderson, J.
Pillay, D.
Delpech, V.
Schwenk, A.
Dunn, D.
Gompels, M.
Hill, T.
Porter, K.
Babiker, A.
Sabin, C.
Babiker, A.
Dunn, D.
Porter, K.
Easterbrook, P.
Waters, A.
Crates, D.
Mohamed-Saad, S.
Fisher, M.
Perry, N.
Pullin, A.
Churchill, D.
Harris, W.
Nelson, M.
Asboe, D.
Bulbeck, S.
Mandalia, S.
Clarke, J.
Gilson, R.
Dodds, J.
Rider, A.
Delpech, V.
Johnson, M.
Youle, M.
Lampe, F.
Smith, C.
Gumley, H.
Chaloner, C.
Ismajani, D.
Walsh, J.
Weber, J.
Cashin, S.
Kemble, C.
Mackie, N.
Orkin, C.
Thomas, R.
Jones, K.
Anderson, J.
Gann, S.
Jones, K.
Leen, C.
Wilson, A.
Schwenk, A.
Ainsworth, J.
Gompels, M.
de Wolf, F.
Bezemer, DO.
Gras, LA.
Kesselring, AM.
van Sighem AI.,
Smit, C.
Zhang, S.
Zaheri, S.
Prins, JM.
Bos, JC.
Eeftinck-Schattenkerk, JK.
Geerlings, SE.
Godfried, MH.
Lange, JM.
van der Meer JT.,
Nellen, FJ.
Olszyna, DP.
van der Poll, M.
Reiss, P.
Sankatsing, SU.
Steingrover, R.
van der Valk, M.
Vermeulen, JN.
Vrouenraets, SM.
van Vugt, M.
Wit, FW.
Schreij, G.
van der Geest, S.
Oude Lashof, A.
Lowe, S.
Verbon, A.
Kuijpers, TW.
Pajkrt, D.
Scherpbier, HJ.
van der Ende ME.,
Bax, H.
van der Feltz, M.
Gelinck, LB.
Nouwen, JL.
Rijnders, BJ.
de Ruiter ED.,
Slobbe, L.
Schurink, CA.
de Vries TE.,
Driessen, G.
van der Flier, M.
Hartwig, NG.
Branger, J.
Kauffmann, RH.
Schippers, EF.
Groeneveld, PH.
Alleman, MA.
ten Kate RW.,
Soetekouw, R.
Kroon, FP.
Arend, SM.
de Boer MG.,
van den Broek PJ.,
van Dissel JT.,
van Nieuwkoop, C.
den Hollander JG.,
Bronsveld, W.
Vriesendorp, R.
Jeurissen, FJ.
Leyten, EM.
van Houte, D.
Polée, MB.
ten Napel CH.,
Kootstra, GJ.
Brinkman, K.
van den Berk GE.,
Blok, WL.
Frissen, PH.
Schouten, WE.
van Eeden, A.
Verhagen, DW.
Mulder, JW.
van Gorp EC.,
Mairuhu, AT.
Steingrover, R.
Wagenaar, J.
Juttmann, JR.
van Kasteren ME.,
Veenstra, J.
Vasmel, WL.
Koopmans, PP.
Brouwer, AM.
Dofferhoff, AS.
de Groot, R.
ter Hofstede HJ.,
Keuter, M.
van der Ven AJ.,
Sprenger, HG.
van Assen, S.
van Leeuwen JT.,
Stek, CJ.
Doedens, R.
Scholvinck, EH.
Hoepelman, IM.
Schneider, MM.
Bonten, MJ.
Ellerbroek, PM.
Jaspers, CA.
Maarschalk-Ellerbroek, LJ.
Oosterheert, JJ.
Peters, EJ.
Mudrikova, T.
Wassenberg, MW.
Weijer, S.
Geelen, SP.
Wolfs, TF.
Danner, SA.
van Agtmael MA.,
Bierman, WF.
Claessen, FA.
Hillebrand, ME.
de Jong EV.,
Kortmann, W.
Perenboom, RM.
bij de Vaate EA.,
Richter, C.
van der Berg, J.
Gisolf, EH.
Tanis, AA.
Duits, AJ.
Winkel, K.
Elisabeth, ST.
Abgrall, S.
Barin, F.
Bentata, M.
Billaud, E.
Boué, F.
Burty, C.
Cabié, A.
Costagliola, D.
Cotte, L.
De Truchis, P.
Duval, X.
Duvivier, C.
Enel, P.
Fredouille-Heripret, L.
Gasnault, J.
Gaud, C.
Gilquin, J.
Grabar, S.
Katlama, C.
Khuong, MA.
Lang, JM.
Lascaux, AS.
Launay, O.
Mahamat, A.
Mary-Krause, M.
Matheron, S.
Meynard, JL.
Pavie, J.
Pialoux, G.
Pilorgé, F.
Poizot-Martin, I.
Pradier, C.
Reynes, J.
Rouveix, E.
Simon, A.
Tattevin, P.
Tissot-Dupont, H.
Viard, JP.
Viget, N.
Salomon, V.
Jacquemet, N.
Abgrall, S.
Costagliola, D.
Grabar, S.
Guiguet, M.
Lanoy, E.
Liévre, L.
Mary-Krause, M.
Selinger-Leneman, H.
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Meynard, JL.
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Mayaud, C.
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Wassoumbou, S.
Oksenhendeler, E.
Gérard, L.
Bernard, L.
De Truchis, P.
Berthé, H.
Domart, Y.
Merrien, D.
Belan, AG.
Gayraud, M.
Bodard, L.
Meudec, A.
Beuscart, C.
Daniel, C.
Pape, E.
Vinceneux, P.
Simonpoli, AM.
Zeng, A.
Fournier, L.
Fuzibet, JG.
Sohn, C.
Rosenthal, E.
Quaranta, M.
Dellamonica, P.
Chaillou, S.
Sabah, M.
Audhuy, B.
Schieber, A.
Moreau, P.
Niault, M.
Vaillant, O.
Huchon, G.
Compagnucci, A.
Szmania Ide, L.
Richier, L.
Lamaury, I.
Saint-Dizier, F.
Garipuy, D.
Gastaut, JA.
Drogoul, MP.
Martin, IP.
Fabre, G.
de Cursay GL.,
Abraham, B.
Perino, C.
Lagarde, P.
David, F.
Roche-Sicot, J.
Saraux, JL.
Leprêtre, A.
Fampin, B.
Uludag, A.
Morin, AS.
Bletry, O.
Zucman, D.
Regnier, A.
Girard, JJ.
Quinsat, DT.
Heripret, L.
Grihon, F.
Houlbert, D.
Ruel, M.
Chemlal, K.
Caron, F.
Debab, Y.
Tremollieres, F.
Perronne, V.
Lepeu, G.
Slama, B.
Perré, P.
Miodovski, C.
Guermonprez, G.
Dulioust, A.
Boudon, P.
Malbec, D.
Patey, O.
Semaille, C.
Deville, J.
Remy, G.
Béguinot, I.
Galanaud, P.
Boue, F.
Chambrin, V.
Pignon, C.
Estocq, GA.
Levy, A.
Delfraissy, JF.
Goujard, C.
Duracinsky, M.
Le Bras, P.
Ngussan, MS.
Peretti, D.
Medintzeff, N.
Lambert, T.
Segeral, O.
Lezeau, P.
Laurian, Y.
Weiss, L.
Buisson, M.
Piketty, C.
Karmochkine, M.
Batisse, D.
Eliaszewitch, M.
Jayle, D.
Tisne- Dessus, D.
Kazatchkine, M.
Leport, C.
Colasante, U.
Jadand, C.
Jestin, C.
Duval, X.
Nouaouia, W.
Boucherit, S.
Vilde, JL.
Girard, PM.
Bollens, D.
Binet, D.
Diallo, B.
Meyohas, MC.
Fonquernie, L.
Lagneau, JL.
Salmon, D.
Guillevin, L.
Tahi, T.
Launay, O.
Pietrie, MP.
Sicard, D.
Stieltjes, N.
Michot, J.
Sobel, A.
Levy, Y.
Bourdillon, F.
Lascaux, AS.
Lelievre, JD.
Dumont, C.
Dupont, B.
Obenga, G.
Viard, JP.
Maignan, A.
Vittecoq, D.
Escaut, L.
Bolliot, C.
Bricaire, F.
Katlama, C.
Schneider, L.
Herson, S.
Simon, A.
Iguertsira, M.
Stein, A.
Tomei, C.
Ravaux, I.
Dhiver, C.
Dupont, HT.
Vallon, A.
Gallais, J.
Gallais, H.
Gastaut, JA.
Drogoul, MP.
Fabre, G.
Dellamonica, P.
Durant, J.
Mondain, V.
Perbost, I.
Cassuto, JP.
Karsenti, JM.
Venti, H.
Fuzibet, JG.
Rosenthal, E.
Ceppi, C.
Quaranta, M.
Krivitsky, JA.
Bentata, M.
Bouchaud, O.
Honore, P.
Sereni, D.
Lascoux, C.
Delgado, J.
Rouzioux, C.
Burgard, M.
Boufassa, L.
Peynet, J.
Hoyos, SP.
Ferreros, I.
Hurtado, I.
del Amo, J.
Jarrín, I.
González, C.
Caro, AM.
Muga, R.
Sanvicens, A.
Clotet, B.
Tor, J.
del Romero, J.
Raposo, P.
Rodríguez, C.
García, S.
Alastrue, I.
Belda, J.
Trullen, P.
Fernández, E.
Santos, C.
Tasa, T.
Zafra, T.
Guerrero, R.
Marco, A.
Quintana, M.
Ruiz, I.
Nuñez, R.
Pérez, R.
Castilla, J.
Guevara, M.
de Mendoza, C.
Zahonero, N.
Groupes de travail
HIV-CAUSAL Collaboration
Liens vers les personnes
Liens vers les unités
ISSN
1473-5571
Statut éditorial
Publié
Date de publication
2010
Volume
24
Numéro
1
Première page
123
Dernière page/numéro d’article
137
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Résumé
OBJECTIVE: To estimate the effect of combined antiretroviral therapy (cART) on mortality among HIV-infected individuals after appropriate adjustment for time-varying confounding by indication.
DESIGN: A collaboration of 12 prospective cohort studies from Europe and the United States (the HIV-CAUSAL Collaboration) that includes 62 760 HIV-infected, therapy-naive individuals followed for an average of 3.3 years. Inverse probability weighting of marginal structural models was used to adjust for measured confounding by indication.
RESULTS: Two thousand and thirty-nine individuals died during the follow-up. The mortality hazard ratio was 0.48 (95% confidence interval 0.41-0.57) for cART initiation versus no initiation. In analyses stratified by CD4 cell count at baseline, the corresponding hazard ratios were 0.29 (0.22-0.37) for less than 100 cells/microl, 0.33 (0.25-0.44) for 100 to less than 200 cells/microl, 0.38 (0.28-0.52) for 200 to less than 350 cells/microl, 0.55 (0.41-0.74) for 350 to less than 500 cells/microl, and 0.77 (0.58-1.01) for 500 cells/microl or more. The estimated hazard ratio varied with years since initiation of cART from 0.57 (0.49-0.67) for less than 1 year since initiation to 0.21 (0.14-0.31) for 5 years or more (P value for trend <0.001).
CONCLUSION: We estimated that cART halved the average mortality rate in HIV-infected individuals. The mortality reduction was greater in those with worse prognosis at the start of follow-up.
Sujets

Adult

Antiretroviral Therap...

CD4 Lymphocyte Count

Drug Administration S...

Drug Therapy, Combina...

Europe/epidemiology

Female

HIV Infections/drug t...

HIV Infections/mortal...

HIV-1

Humans

Male

Middle Aged

Proportional Hazards ...

Time Factors

United States/epidemi...

Viral Load

PID Serval
serval:BIB_E2F47CDCEA4E
DOI
PMID
WOS
Permalien
Date de création
2010-02-15T10:03:09.268Z
Date de création dans IRIS
2025-05-21T07:25:26Z