Titre
The effect of a period of intensive exercise on the isoform test to detect growth hormone doping in sports.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Voss, S.C.
Auteure/Auteur
Giraud, S.
Auteure/Auteur
Alsayrafi, M.
Auteure/Auteur
Bourdon, P.C.
Auteure/Auteur
Schumacher, Y.O.
Auteure/Auteur
Saugy, M.
Auteure/Auteur
Robinson, N.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1532-2238
Statut éditorial
Publié
Date de publication
2013
Volume
23
Numéro
4
Première page
105
Dernière page/numéro d’article
108
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
OBJECTIVE: The major objective of this study was to investigate the effects of several days of intense exercise on growth hormone (hGH) testing using the World Anti-Doping Agencies hGH isoform differential immunoassays. Additionally the effects of circadian variation and exercise type on the isoform ratios were also investigated.
STUDY DESIGN: 15 male athletes performed a simulated nine day cycling stage race. Blood samples were collected twice daily over a period of 15days (stage race+three days before and after). hGH isoforms were analysed by the official WADA immunoassays (CMZ Assay GmbH).
RESULTS: All measured isoform ratios were far below the WADA decision limits for an adverse analytical finding. Changes in the isoform ratios could not be clearly connected to circadian variation, exercise duration or intensity.
CONCLUSIONS: The present study demonstrates that the hGH isoform ratios are not significantly affected by exercise or circadian variation. We demonstrated that heavy, long term exercise does not interfere with the decision limits for an adverse analytical finding.
STUDY DESIGN: 15 male athletes performed a simulated nine day cycling stage race. Blood samples were collected twice daily over a period of 15days (stage race+three days before and after). hGH isoforms were analysed by the official WADA immunoassays (CMZ Assay GmbH).
RESULTS: All measured isoform ratios were far below the WADA decision limits for an adverse analytical finding. Changes in the isoform ratios could not be clearly connected to circadian variation, exercise duration or intensity.
CONCLUSIONS: The present study demonstrates that the hGH isoform ratios are not significantly affected by exercise or circadian variation. We demonstrated that heavy, long term exercise does not interfere with the decision limits for an adverse analytical finding.
PID Serval
serval:BIB_DACC6653F554
PMID
Date de création
2013-07-26T15:11:08.744Z
Date de création dans IRIS
2025-05-21T06:19:50Z