Titre
Porto-sinusoidal vascular disorder.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
De Gottardi, A.
Auteure/Auteur
Sempoux, C.
Auteure/Auteur
Berzigotti, A.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1600-0641
Statut éditorial
Publié
Date de publication
2022-10
Volume
77
Numéro
4
Première page
1124
Dernière page/numéro d’article
1135
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
It is well established that portal hypertension can occur in the absence of cirrhosis, as reported in patients with immune disorders, infections and thrombophilia. However, similar histological abnormalities primarily affecting the hepatic sinusoidal and (peri)portal vasculature have also been observed in patients without portal hypertension. Thus, the term porto-sinusoidal vascular disorder (PSVD) has recently been introduced to describe a group of vascular diseases of the liver featuring lesions encompassing the portal venules and sinusoids, irrespective of the presence/absence of portal hypertension. Liver biopsy is fundamental for PSVD diagnosis. Specific histology findings include nodular regenerative hyperplasia, obliterative portal venopathy/portal vein stenosis and incomplete septal fibrosis/cirrhosis. Since other conditions including alcohol-related and non-alcoholic fatty liver disease, or viral hepatitis, or the presence of portal vein thrombosis may occur in patients with PSVD, their relative contribution to liver damage should be carefully assessed. In addition to histology and clinical diagnostic criteria, imaging and non-invasive tests such as liver and spleen stiffness measurements could aid in the diagnostic workup. The introduction of PSVD as a novel clinical entity will facilitate collaborative studies and investigations into the underlying molecular pathomechanisms encompassed by this term.
Sujets
PID Serval
serval:BIB_B35EED5B7938
PMID
Open Access
Oui
Date de création
2022-06-13T06:06:42.329Z
Date de création dans IRIS
2025-05-21T01:47:39Z
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Nom
35690264.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.96 MB
Format
Adobe PDF
PID Serval
serval:BIB_B35EED5B7938.P001
URN
urn:nbn:ch:serval-BIB_B35EED5B79386
Somme de contrôle
(MD5):c08f5fb1c98cfb3375034acc21960b80