Titre
Effect of modafinil on subjective fatigue in multiple sclerosis and stroke patients.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Brioschi, Andrea
Auteure/Auteur
Gramigna, Sandrine
Auteure/Auteur
Werth, Esther
Auteure/Auteur
Staub, Fabienne
Auteure/Auteur
Ruffieux, Christiane
Auteure/Auteur
Bassetti, Claudio
Auteure/Auteur
Schluep, Myriam
Auteure/Auteur
Annoni, Jean-Marie
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1421-9913[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
62
Numéro
4
Première page
243
Dernière page/numéro d’article
249
Peer-reviewed
Oui
Langue
anglais
Résumé
BACKGROUND: Modafinil has anecdotal response to neurological fatigue, but such an effect may depend on the type and location of cerebral impairment. OBJECTIVES: It was the aim of this study to compare fatigue observed in different neurological pathologies, to evaluate the tolerability to modafinil, and to describe changes in subjective fatigue. METHODS: We enrolled 14 brainstem or diencephalic stroke (BDS) patients, 9 cortical stroke (CS) patients and 17 multiple sclerosis (MS) patients. The Fatigue Assessment Instrument severity scale was performed at baseline, after 3 months of modafinil and after 1 month of washout. Cognition, mood and somnolence were assessed. A subgroup of 14 patients underwent activity measures before and during treatment. RESULTS: Thirty-one patients completed the study (10 BDS, 9 CS, 12 MS). The responder profile is more frequent in MS than in CS (p = 0.04), and in BDS than in CS patients (p = 0.04). Actiwatch measures showed no changes in activity during, before and after therapy. CONCLUSION: Modafinil was tolerated in 75% of patients at small doses and seemed to improve the severity of fatigue in the MS and BDS groups but not in the CS group. There was no modification in measured physical activity.
Sujets
PID Serval
serval:BIB_C3EECA832B45
PMID
Date de création
2009-12-29T13:05:29.684Z
Date de création dans IRIS
2025-05-21T04:29:29Z