Titre
Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Simicic, D.
Auteure/Auteur
Rackayova, V.
Auteure/Auteur
Braissant, O.
Auteure/Auteur
Toso, C.
Auteure/Auteur
Oldani, G.
Auteure/Auteur
Sessa, D.
Auteure/Auteur
McLin, V.A.
Auteure/Auteur
Cudalbu, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1573-7365
Statut éditorial
Publié
Date de publication
2023-08
Volume
38
Numéro
6
Première page
1999
Dernière page/numéro d’article
2012
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Chronic liver disease (CLD) is a serious condition where various toxins present in the blood affect the brain leading to type C hepatic encephalopathy (HE). Both adults and children are impacted, while children may display unique vulnerabilities depending on the affected window of brain development.We aimed to use the advantages of high field proton Magnetic Resonance Spectroscopy ( <sup>1</sup> H MRS) to study longitudinally the neurometabolic and behavioural effects of Bile Duct Ligation (animal model of CLD-induced type C HE) on rats at post-natal day 15 (p15) to get closer to neonatal onset liver disease. Furthermore, we compared two sets of animals (p15 and p21-previously published) to evaluate whether the brain responds differently to CLD according to age onset.We showed for the first time that when CLD was acquired at p15, the rats presented the typical signs of CLD, i.e. rise in plasma bilirubin and ammonium, and developed the characteristic brain metabolic changes associated with type C HE (e.g. glutamine increase and osmolytes decrease). When compared to rats that acquired CLD at p21, p15 rats did not show any significant difference in plasma biochemistry, but displayed a delayed increase in brain glutamine and decrease in total-choline. The changes in neurotransmitters were milder than in p21 rats. Moreover, p15 rats showed an earlier increase in brain lactate and a different antioxidant response. These findings offer tentative pointers as to which neurodevelopmental processes may be impacted and raise the question of whether similar changes might exist in humans but are missed owing to <sup>1</sup> H MRS methodological limitations in field strength of clinical magnet.
PID Serval
serval:BIB_AF6E83A093E9
PMID
Open Access
Oui
Date de création
2023-05-15T12:42:24.443Z
Date de création dans IRIS
2025-05-21T02:15:45Z
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Nom
2023-MetabBrainDis-Simicic.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
3.59 MB
Format
Adobe PDF
PID Serval
serval:BIB_AF6E83A093E9.P001
URN
urn:nbn:ch:serval-BIB_AF6E83A093E99
Somme de contrôle
(MD5):22563e17160eea42afeeb8544a32d55d