Titre
Prevention of vitamin K deficiency bleeding with three oral mixed micellar phylloquinone doses: results of a 6-year (2005-2011) surveillance in Switzerland.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Laubscher, B.
Auteure/Auteur
Bänziger, O.
Auteure/Auteur
Schubiger, G.
Auteure/Auteur
Contributrices/contributeurs
Aebi, Ch.
Antonelli, E.
Bär, W.
Bianchetti, M.
Blumberg, A.
Bucher, H.
Buetti, L.
Cachat, F.
Carrel, O.
Cattin, P.
Corboz, A.
Däster, C.
Diebold, P.
Dolivo, P.
Farron, F.
Fluri, S.
Gebauer, M.
Gehri, M.
Giannoni, E.
Haenggeli, C.
Hodel, M.
Hüppi, P.
Imahorn, P.
Irion, O.
Kind, C.
Kistler, W.
Knöpfli, B.
Kottanattu, L.
Lapaire, O.
Laubscher, B.
Leuthardt, R.
Lips, U.
Malzacher, A.
Dougall, J.
Meyer, P.
Micheli, JL.
Minet, JC.
Mönkhoff, M.
Neuhaus, T.
Pezzoli, V.
Piol, N.
Posfay Barbe, K.
Reinhard, L.
Renevey, F.
Roten, H.
Rudin, C.
Schlumbom, V.
Sizonenko, S.
Stirnemann, S.
Stocker, S.
Stüssi, C.
Tabin, R.
Terrier, P.
Villiger, R.
Wellmann, S.
Wildhaber, J.
Wopmann, M.
Zeilinger, G.
Zemmouri, A.
Zimmermann, U.
Groupes de travail
Swiss Paediatric Surveillance Unit (SPSU)
Liens vers les personnes
Liens vers les unités
ISSN
1432-1076
Statut éditorial
Publié
Date de publication
2013
Volume
172
Numéro
3
Première page
357
Dernière page/numéro d’article
360
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: Original article
Résumé
In 2003, the Swiss guidelines to prevent vitamin K deficiency bleeding (VKDB) were adapted. As two oral doses (2 mg, hour/day 4) of mixed micellar VK preparation had failed to abolish late VKDB, a third dose (week 4) was introduced. This report summarizes the new guidelines acceptance by Swiss pediatricians and the results of a prospective 6-year surveillance to study their influence on the incidence of VKDB. The new guidelines acceptance by Swiss pediatricians was evaluated by a questionnaire sent to all pediatricians of the Swiss Society of Paediatrics. With the help of the Swiss Paediatric Surveillance Unit, the incidence of VKDB was monitored prospectively from July 1, 2005 until June 30, 2011. Over a 6-year period (458,184 live births), there was one case of early and four cases of late VKDB. Overall incidence was 1.09/10(5) (95 % confidence intervals (CI) 0.4-2.6). Late VKDB incidence was 0.87/10(5) (95 % CI 0.24-2.24). All four infants with late VKDB had an undiagnosed cholestasis at the time of bleeding; parents of 3/4 had refused VK prophylaxis, and in 1/4, the third VK dose had been forgotten. Compared with historical control who had received only two oral doses of mixed micellar VK (18 cases for 475,372 live births), the incidence of late VKDB was significantly lower with three oral doses (Chi(2),Yates correction, P = 0.007). CONCLUSION: VKDB prophylaxis with 3 × 2 mg oral doses of mixed micellar VK seems to prevent adequately infants from VKDB. The main risk factors for VKDB in breast-fed infants are parental VK prophylaxis refusal or an unknown cholestasis.
PID Serval
serval:BIB_87B599DDBECC
PMID
Open Access
Oui
Date de création
2013-04-12T16:47:57.539Z
Date de création dans IRIS
2025-05-21T01:34:58Z
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Nom
REF.pdf
Version du manuscrit
published
Taille
126.2 KB
Format
Adobe PDF
PID Serval
serval:BIB_87B599DDBECC.P001
URN
urn:nbn:ch:serval-BIB_87B599DDBECC0
Somme de contrôle
(MD5):b3c843ecc6faf96a083d1ab4ee920ea4