Titre
Cambiando la vía de manejo del cáncer de próstata: ¿Por qué la Terapia Focal es un paso adelante? [Changing the prostate cancer management pathway: why Focal Therapy is a step forward]
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Archivos espanoles de urologia
Auteur(s)
Marra, G.
Auteure/Auteur
Gontero, P.
Auteure/Auteur
Valerio, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0004-0614
Statut éditorial
Publié
Date de publication
2016-07
Volume
69
Numéro
6
Première page
271
Dernière page/numéro d’article
280
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Prostate Cancer (PCa) remains an exception among solid cancers since organ-sparing procedures are not considered as a standard option. Despite most men harbour low to intermediate risk disease at diagnosis, the vast majority are advised towards radical treatment. We performed a literature review to highlight and discuss why focal therapy (FT) would represent a feasible and attractive option in appropriately selected men. The rationale supporting this strategy relies in epidemiological, pathological, molecular and clinical findings. These include the shift towards the diagnosis of less aggressive and unifocal PCas, the presence of an identifiable index lesion which drives the natural history of the disease together with the absence of significant disease elsewhere in the gland in many patients. New diagnostic tools, especially multiparametric MRI, allow the detection of the index lesion with good accuracy and high reliability. FT might provide acceptable disease control and at the same time substantially reduce treatment related side-effects in those men who are eligible for such strategy. To allow its adoption as a standard of care, future studies need to address current limitations such as the lack of direct comparative research against standard treatment, as well as long-term disease-control outcomes.
PID Serval
serval:BIB_C0C94E3CD803
PMID
Date de création
2016-07-25T15:45:08.309Z
Date de création dans IRIS
2025-05-20T22:44:36Z