Titre
Human cardiospheres as a source of multipotent stem and progenitor cells.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Barile, L.
Auteure/Auteur
Gherghiceanu, M.
Auteure/Auteur
Popescu, L.M.
Auteure/Auteur
Moccetti, T.
Auteure/Auteur
Vassalli, G.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1687-966X
Statut éditorial
Publié
Date de publication
2013
Volume
2013
Première page
916837
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish Document Type: Review; PDF : Review Article
Résumé
Cardiospheres (CSs) are self-assembling multicellular clusters from the cellular outgrowth from cardiac explants cultured in nonadhesive substrates. They contain a core of primitive, proliferating cells, and an outer layer of mesenchymal/stromal cells and differentiating cells that express cardiomyocyte proteins and connexin 43. Because CSs contain both primitive cells and committed progenitors for the three major cell types present in the heart, that is, cardiomyocytes, endothelial cells, and smooth muscle cells, and because they are derived from percutaneous endomyocardial biopsies, they represent an attractive cell source for cardiac regeneration. In preclinical studies, CS-derived cells (CDCs) delivered to infarcted hearts resulted in improved cardiac function. CDCs have been tested safely in an initial phase-1 clinical trial in patients after myocardial infarction. Whether or not CDCs are superior to purified populations, for example, c-kit(+) cardiac stem cells, or to gene therapy approaches for cardiac regeneration remains to be evaluated.
PID Serval
serval:BIB_7B755E337E4C
PMID
Open Access
Oui
Date de création
2013-09-20T16:37:21.863Z
Date de création dans IRIS
2025-05-20T21:00:44Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
BIB_7B755E337E4C.P001.pdf
Version du manuscrit
preprint
Taille
3.37 MB
Format
Adobe PDF
PID Serval
serval:BIB_7B755E337E4C.P001
URN
urn:nbn:ch:serval-BIB_7B755E337E4C6
Somme de contrôle
(MD5):ddd6387cea7105b17577b963df8dae0d