Titre
Interobserver variability in target definition for stereotactic arrhythmia radioablation.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
van der Ree, M.H.
Auteure/Auteur
Cuculich, P.S.
Auteure/Auteur
van Herk, M.
Auteure/Auteur
Hugo, G.D.
Auteure/Auteur
Balt, J.C.
Auteure/Auteur
Bates, M.
Auteure/Auteur
Ho, G.
Auteure/Auteur
Pruvot, E.
Auteure/Auteur
Herrera-Siklody, C.
Auteure/Auteur
Hoeksema, W.F.
Auteure/Auteur
Lee, J.
Auteure/Auteur
Lloyd, M.S.
Auteure/Auteur
Kemme, MJB
Auteure/Auteur
Sacher, F.
Auteure/Auteur
Tixier, R.
Auteure/Auteur
Verhoeff, JJC
Auteure/Auteur
Balgobind, B.V.
Auteure/Auteur
Robinson, C.G.
Auteure/Auteur
Rasch, CRN
Auteure/Auteur
Postema, P.G.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2297-055X
Statut éditorial
Publié
Date de publication
2023
Volume
10
Première page
1267800
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Stereotactic arrhythmia radioablation (STAR) is a potential new therapy for patients with refractory ventricular tachycardia (VT). The arrhythmogenic substrate (target) is synthesized from clinical and electro-anatomical information. This study was designed to evaluate the baseline interobserver variability in target delineation for STAR.
Delineation software designed for research purposes was used. The study was split into three phases. Firstly, electrophysiologists delineated a well-defined structure in three patients (spinal canal). Secondly, observers delineated the VT-target in three patients based on case descriptions. To evaluate baseline performance, a basic workflow approach was used, no advanced techniques were allowed. Thirdly, observers delineated three predefined segments from the 17-segment model. Interobserver variability was evaluated by assessing volumes, variation in distance to the median volume expressed by the root-mean-square of the standard deviation (RMS-SD) over the target volume, and the Dice-coefficient.
Ten electrophysiologists completed the study. For the first phase interobserver variability was low as indicated by low variation in distance to the median volume (RMS-SD range: 0.02-0.02 cm) and high Dice-coefficients (mean: 0.97 ± 0.01). In the second phase distance to the median volume was large (RMS-SD range: 0.52-1.02 cm) and the Dice-coefficients low (mean: 0.40 ± 0.15). In the third phase, similar results were observed (RMS-SD range: 0.51-1.55 cm, Dice-coefficient mean: 0.31 ± 0.21).
Interobserver variability is high for manual delineation of the VT-target and ventricular segments. This evaluation of the baseline observer variation shows that there is a need for methods and tools to improve variability and allows for future comparison of interventions aiming to reduce observer variation, for STAR but possibly also for catheter ablation.
Delineation software designed for research purposes was used. The study was split into three phases. Firstly, electrophysiologists delineated a well-defined structure in three patients (spinal canal). Secondly, observers delineated the VT-target in three patients based on case descriptions. To evaluate baseline performance, a basic workflow approach was used, no advanced techniques were allowed. Thirdly, observers delineated three predefined segments from the 17-segment model. Interobserver variability was evaluated by assessing volumes, variation in distance to the median volume expressed by the root-mean-square of the standard deviation (RMS-SD) over the target volume, and the Dice-coefficient.
Ten electrophysiologists completed the study. For the first phase interobserver variability was low as indicated by low variation in distance to the median volume (RMS-SD range: 0.02-0.02 cm) and high Dice-coefficients (mean: 0.97 ± 0.01). In the second phase distance to the median volume was large (RMS-SD range: 0.52-1.02 cm) and the Dice-coefficients low (mean: 0.40 ± 0.15). In the third phase, similar results were observed (RMS-SD range: 0.51-1.55 cm, Dice-coefficient mean: 0.31 ± 0.21).
Interobserver variability is high for manual delineation of the VT-target and ventricular segments. This evaluation of the baseline observer variation shows that there is a need for methods and tools to improve variability and allows for future comparison of interventions aiming to reduce observer variation, for STAR but possibly also for catheter ablation.
PID Serval
serval:BIB_84BB622557AE
PMID
Open Access
Oui
Date de création
2023-10-09T11:38:21.651Z
Date de création dans IRIS
2025-05-20T21:00:25Z
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Nom
37799779_BIB_84BB622557AE.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
4.71 MB
Format
Adobe PDF
PID Serval
serval:BIB_84BB622557AE.P001
URN
urn:nbn:ch:serval-BIB_84BB622557AE7
Somme de contrôle
(MD5):dc265ec677cfc03c7b3681dcc0ac84e4