Titre
mtDB: Human Mitochondrial Genome Database, a resource for population genetics and medical sciences
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Ingman, M.
Auteure/Auteur
Gyllensten, U.
Auteure/Auteur
Liens vers les unités
ISSN
1362-4962
Statut éditorial
Publié
Date de publication
2006
Volume
34
Numéro
Database issue
Première page
D749
Dernière page/numéro d’article
D751
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The mitochondrial genome, contained in the subcellular mitochondrial network, encodes a small number of peptides pivotal for cellular energy production. Mitochondrial genes are highly polymorphic and cataloguing existing variation is of interest for medical scientists involved in the identification of mutations causing mitochondrial dysfunction, as well as for population genetics studies. Human Mitochondrial Genome Database (mtDB) (http://www.genpat.uu.se/mtDB) has provided a comprehensive database of complete human mitochondrial genomes since early 2000. At this time, owing to an increase in the number of published complete human mitochondrial genome sequences, it became necessary to provide a web-based database of human whole genome and complete coding region sequences. As of August 2005 this database contains 2104 sequences (1544 complete genome and 560 coding region) available to download or search for specific polymorphisms. Of special interest to medical researchers and population geneticists evaluating specific positions is a complete list of (currently 3311) mitochondrial polymorphisms among these sequences. Recent expansions in the capabilities of mtDB include a haplotype search function and the ability to identify and download sequences carrying particular variants.
PID Serval
serval:BIB_9D7629A62E8C
PMID
Open Access
Oui
Date de création
2018-07-13T08:00:31.363Z
Date de création dans IRIS
2025-05-21T03:51:05Z
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Nom
16381973_BIB_9D7629A62E8C.pdf
Version du manuscrit
published
Taille
119.97 KB
Format
Adobe PDF
PID Serval
serval:BIB_9D7629A62E8C.P001
URN
urn:nbn:ch:serval-BIB_9D7629A62E8C9
Somme de contrôle
(MD5):b44f23991517a70ba7c4680884fb338e