Titre
Mécanismes physiopathologiques impliqués dans la dysfonction d'organes au cours du sepsis [Pathophysiological mechanisms of organ dysfunction in sepsis]
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Calderari, B.
Auteure/Auteur
Liaudet, L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1660-9379
Statut éditorial
Publié
Date de publication
2010-12-15
Volume
6
Numéro
275
Première page
2406
Dernière page/numéro d’article
2409
Peer-reviewed
Oui
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Sepsis is defined as the systemic inflammatory response to an infection. The occurrence of organ dysfunction increases the severity of sepsis. Complex interactions between multiple immunomodulating mediators and various cell populations, activated secondarily to the initial infectious insult, promote the development of organ dysfunction in sepsis. Although septic organ dysfunction has long been considered as the end result of chaotic, uncontrolled and deregulated inflammatory cascades, it might instead represent an adaptive response to avoid the occurrence of irreversible tissue damage and end-organ injury. In this article, we review the major mechanisms involved in organ dysfunction during sepsis, and also present the concept of organ dysfunction as an adaptive response to the septic process.
Sujets
PID Serval
serval:BIB_2322D5381C9B
PMID
Date de création
2011-03-09T08:23:02.591Z
Date de création dans IRIS
2025-05-20T14:02:14Z
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Nom
RMS_idPAS_D_ISBN_pu2010-45s_sa05_art05.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
534.8 KB
Format
Adobe PDF
PID Serval
serval:BIB_2322D5381C9B.P001
URN
urn:nbn:ch:serval-BIB_2322D5381C9B3
Somme de contrôle
(MD5):9209b936b4e276b7c98ac1696f657262