Titre
Sirolimus-associated eyelid edema in kidney transplant recipients
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Mohaupt, M. G.
Auteure/Auteur
Vogt, B.
Auteure/Auteur
Frey, F. J.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0041-1337
Statut éditorial
Publié
Date de publication
2001-07
Volume
72
Numéro
1
Première page
162
Dernière page/numéro d’article
4
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Jul 15
Journal Article
Randomized Controlled Trial --- Old month value: Jul 15
Résumé
BACKGROUND: The immunosuppressant sirolimus is effective in preventing acute rejection episodes. So far, unusual edema formation has not been reported as a side effect. METHODS: Two groups of patients with renal transplants, consisting of 11 patients each, were followed for up to 29 months. The immunosuppressive regimen was either sirolimus and prednisone with or without cyclosporine or azathioprine/mycophenolate and prednisone with cyclosporine. Routine follow-up included a thorough clinical investigation. Edema formation was documented photographically. RESULTS: In 5 of the 11 patients treated with sirolimus uni- or bilateral, non-itching, eyelid edema was observed. After discontinuation of sirolimus, lid edema disappeared. The duration until recovery varied from weeks to months. No cause of edema formation other than the treatment with sirolimus was detected. CONCLUSIONS: Severe eyelid edema formation seems to be associated with sirolimus treatment. The underlying mechanism is unknown.
Sujets
PID Serval
serval:BIB_89F3E47E2581
PMID
Date de création
2008-01-25T12:03:10.584Z
Date de création dans IRIS
2025-05-21T00:03:32Z