Titre
Dissection aortique aiguë: utilité diagnostique des D-dimères [Acute aortic dissection: diagnostic usefulness of D-dimer]
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Fournier, Y.
Auteure/Auteur
Moix, P.A.
Auteure/Auteur
Hugli, O.
Auteure/Auteur
Liens vers les personnes
ISSN
1660-9379
Statut éditorial
Publié
Date de publication
2008
Volume
4
Numéro
167
Première page
1759
Dernière page/numéro d’article
1763
Langue
français
Résumé
Acute aortic dissection (AAD) is uncommon, and associated with high morbidity and mortality rates. Positive or negative likelihood ratios of clinical parameters, ECG and chest x-ray do not allow to rule in or rule out AAD. Angio-CT, transoesophageal echocardiography, and MRI are validated tools for AAD diagnosis, although they are invasive and associated with significant complications. In several studies, D-dimer level within the normal range appears to have a negative predictive value that is low enough to rule out AAD. However, flaws of study design, heterogeneity of D-dimer tests and of their cut-offs (from 100 to 900 microg/l), and the absence of a validated workup strategy are strong arguments against the current use of D-dimer as a unique test to rule out AAD in clinical practice.
PID Serval
serval:BIB_81AD30112912
PMID
Date de création
2008-12-16T13:13:31.213Z
Date de création dans IRIS
2025-05-21T04:41:53Z