Titre
Quality of Life After Poor-Grade Aneurysmal Subarachnoid Hemorrhage.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Goldberg, J.
Auteure/Auteur
Z'Graggen, W.J.
Auteure/Auteur
Hlavica, M.
Auteure/Auteur
Branca, M.
Auteure/Auteur
Marbacher, S.
Auteure/Auteur
D'Alonzo, D.
Auteure/Auteur
Fandino, J.
Auteure/Auteur
Stienen, M.N.
Auteure/Auteur
Neidert, M.C.
Auteure/Auteur
Burkhardt, J.K.
Auteure/Auteur
Regli, L.
Auteure/Auteur
Seule, M.
Auteure/Auteur
Roethlisberger, M.
Auteure/Auteur
Guzman, R.
Auteure/Auteur
Zumofen, D.W.
Auteure/Auteur
Maduri, R.
Auteure/Auteur
Daniel, R.T.
Auteure/Auteur
El Rahal, A.
Auteure/Auteur
Corniola, M.V.
Auteure/Auteur
Bijlenga, P.
Auteure/Auteur
Schaller, K.
Auteure/Auteur
Rölz, R.
Auteure/Auteur
Scheiwe, C.
Auteure/Auteur
Shah, M.
Auteure/Auteur
Heiland, D.H.
Auteure/Auteur
Schnell, O.
Auteure/Auteur
Beck, J.
Auteure/Auteur
Raabe, A.
Auteure/Auteur
Fung, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1524-4040
Statut éditorial
Publié
Date de publication
2023-05-01
Volume
92
Numéro
5
Première page
1052
Dernière page/numéro d’article
1057
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Observational Study ; Multicenter Study ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Poor-grade aneurysmal subarachnoid hemorrhage (aSAH) is associated with high mortality and poor disability outcome. Data on quality of life (QoL) among survivors are scarce because patients with poor-grade aSAH are underrepresented in clinical studies reporting on QoL after aSAH.
To provide prospective QoL data on survivors of poor-grade aSAH to aid clinical decision making and counseling of relatives.
The herniation World Federation of Neurosurgical Societies scale study was a prospective observational multicenter study in patients with poor-grade (World Federation of Neurosurgical Societies grades 4 & 5) aSAH. We collected data during a structured telephone interview 6 and 12 months after ictus. QoL was measured using the EuroQoL - 5 Dimensions - 3 Levels (EQ-5D-3L) questionnaire, with 0 representing a health state equivalent to death and 1 to perfect health. Disability outcome for favorable and unfavorable outcomes was measured with the modified Rankin Scale.
Two hundred-fifty patients were enrolled, of whom 237 were included in the analysis after 6 months and 223 after 12 months. After 6 months, 118 (49.8%) patients were alive, and after 12 months, 104 (46.6%) patients were alive. Of those, 95 (80.5%) and 89 (85.6%) reached a favorable outcome with mean EQ-5D-3L index values of 0.85 (±0.18) and 0.86 (±0.18). After 6 and 12 months, 23 (19.5%) and 15 (14.4%) of those alive had an unfavorable outcome with mean EQ-5D-3L index values of 0.27 (±0.25) and 0.19 (±0.14).
Despite high initial mortality, the proportion of poor-grade aSAH survivors with good QoL is reasonably large. Only a minority of survivors reports poor QoL and requires permanent care.
To provide prospective QoL data on survivors of poor-grade aSAH to aid clinical decision making and counseling of relatives.
The herniation World Federation of Neurosurgical Societies scale study was a prospective observational multicenter study in patients with poor-grade (World Federation of Neurosurgical Societies grades 4 & 5) aSAH. We collected data during a structured telephone interview 6 and 12 months after ictus. QoL was measured using the EuroQoL - 5 Dimensions - 3 Levels (EQ-5D-3L) questionnaire, with 0 representing a health state equivalent to death and 1 to perfect health. Disability outcome for favorable and unfavorable outcomes was measured with the modified Rankin Scale.
Two hundred-fifty patients were enrolled, of whom 237 were included in the analysis after 6 months and 223 after 12 months. After 6 months, 118 (49.8%) patients were alive, and after 12 months, 104 (46.6%) patients were alive. Of those, 95 (80.5%) and 89 (85.6%) reached a favorable outcome with mean EQ-5D-3L index values of 0.85 (±0.18) and 0.86 (±0.18). After 6 and 12 months, 23 (19.5%) and 15 (14.4%) of those alive had an unfavorable outcome with mean EQ-5D-3L index values of 0.27 (±0.25) and 0.19 (±0.14).
Despite high initial mortality, the proportion of poor-grade aSAH survivors with good QoL is reasonably large. Only a minority of survivors reports poor QoL and requires permanent care.
PID Serval
serval:BIB_2248B4D6C2A9
PMID
Open Access
Oui
Date de création
2023-02-10T15:49:42.428Z
Date de création dans IRIS
2025-05-20T13:21:15Z
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36700700.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
994.57 KB
Format
Adobe PDF
PID Serval
serval:BIB_2248B4D6C2A9.P001
URN
urn:nbn:ch:serval-BIB_2248B4D6C2A96
Somme de contrôle
(MD5):45387ab7aa95d2af7e57afc5c025d5df