Titre
Receptor-mediated phagocytosis by macrophages induces a calcium-dependent transient increase in c-fos transcription.
Type
article
Institution
Externe
Périodique
Auteur(s)
Collart, M.A.
Auteure/Auteur
Belin, D.
Auteure/Auteur
Briottet, C.
Auteure/Auteur
Thorens, B.
Auteure/Auteur
Vassalli, J.D.
Auteure/Auteur
Vassalli, P.
Auteure/Auteur
Liens vers les personnes
ISSN
0950-9232
Statut éditorial
Publié
Date de publication
1989-02
Volume
4
Numéro
2
Première page
237
Dernière page/numéro d’article
241
Peer-reviewed
Oui
Langue
anglais
Résumé
The transcription of the c-fos gene and the level of c-fos mRNA in mouse peritoneal macrophages are rapidly, strongly and transiently increased after Fc- and C3b-mediated phagocytosis, but not after phagocytosis of latex particles. In order to induce both phagocytosis and a rise in c-fos mRNA, binding to receptors must be followed by mobilization of Ca++ from intracellular Induction of c-fos transcription in macrophages by other agents acting through different intracellular "messengers', i.e. phorbol esters (protein kinase C), cholera toxin (cAMP) and dexamethasone (glucocorticoid receptor) also depends on intracellular Ca++. In all these conditions, induction of c-fos transcription is inhibited by the calmodulin antagonist W7, suggesting a common Ca++-dependent pathway for c-fos gene activation in macrophages.
PID Serval
serval:BIB_8A33953DEF32
PMID
Date de création
2008-01-24T12:41:43.179Z
Date de création dans IRIS
2025-05-21T00:03:45Z