Titre
MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part I, the solid gland.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Galluzzi, P.
Auteure/Auteur
de Jong, M.C.
Auteure/Auteur
Sirin, S.
Auteure/Auteur
Maeder, P.
Auteure/Auteur
Piu, P.
Auteure/Auteur
Cerase, A.
Auteure/Auteur
Monti, L.
Auteure/Auteur
Brisse, H.J.
Auteure/Auteur
Castelijns, J.A.
Auteure/Auteur
de Graaf, P.
Auteure/Auteur
Goericke, S.L.
Auteure/Auteur
Groupes de travail
European Retinoblastoma Imaging Collaboration (ERIC)
Liens vers les personnes
Liens vers les unités
ISSN
1432-1920
Statut éditorial
Publié
Date de publication
2016-07
Volume
58
Numéro
7
Première page
705
Dernière page/numéro d’article
712
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
Differentiation between normal solid (non-cystic) pineal glands and pineal pathologies on brain MRI is difficult. The aim of this study was to assess the size of the solid pineal gland in children (0-5 years) and compare the findings with published pineoblastoma cases.
We retrospectively analyzed the size (width, height, planimetric area) of solid pineal glands in 184 non-retinoblastoma patients (73 female, 111 male) aged 0-5 years on MRI. The effect of age and gender on gland size was evaluated. Linear regression analysis was performed to analyze the relation between size and age. Ninety-nine percent prediction intervals around the mean were added to construct a normal size range per age, with the upper bound of the predictive interval as the parameter of interest as a cutoff for normalcy.
There was no significant interaction of gender and age for all the three pineal gland parameters (width, height, and area). Linear regression analysis gave 99 % upper prediction bounds of 7.9, 4.8, and 25.4 mm(2), respectively, for width, height, and area. The slopes (size increase per month) of each parameter were 0.046, 0.023, and 0.202, respectively. Ninety-three percent (95 % CI 66-100 %) of asymptomatic solid pineoblastomas were larger in size than the 99 % upper bound.
This study establishes norms for solid pineal gland size in non-retinoblastoma children aged 0-5 years. Knowledge of the size of the normal pineal gland is helpful for detection of pineal gland abnormalities, particularly pineoblastoma.
We retrospectively analyzed the size (width, height, planimetric area) of solid pineal glands in 184 non-retinoblastoma patients (73 female, 111 male) aged 0-5 years on MRI. The effect of age and gender on gland size was evaluated. Linear regression analysis was performed to analyze the relation between size and age. Ninety-nine percent prediction intervals around the mean were added to construct a normal size range per age, with the upper bound of the predictive interval as the parameter of interest as a cutoff for normalcy.
There was no significant interaction of gender and age for all the three pineal gland parameters (width, height, and area). Linear regression analysis gave 99 % upper prediction bounds of 7.9, 4.8, and 25.4 mm(2), respectively, for width, height, and area. The slopes (size increase per month) of each parameter were 0.046, 0.023, and 0.202, respectively. Ninety-three percent (95 % CI 66-100 %) of asymptomatic solid pineoblastomas were larger in size than the 99 % upper bound.
This study establishes norms for solid pineal gland size in non-retinoblastoma children aged 0-5 years. Knowledge of the size of the normal pineal gland is helpful for detection of pineal gland abnormalities, particularly pineoblastoma.
Sujets
PID Serval
serval:BIB_032ABB9AA448
PMID
Open Access
Oui
Date de création
2016-05-17T17:00:31.757Z
Date de création dans IRIS
2025-05-20T17:37:21Z
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Nom
BIB_032ABB9AA448.P001.pdf
Version du manuscrit
preprint
Taille
612.24 KB
Format
Adobe PDF
PID Serval
serval:BIB_032ABB9AA448.P001
URN
urn:nbn:ch:serval-BIB_032ABB9AA4484
Somme de contrôle
(MD5):fe8c974fb46d19b3dc7f0a7e30fb9acb