Titre
Direct electrical stimulation using a battery-operated device for induction and modulation of colonic contractions in pigs.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Bertschi, M.
Auteure/Auteur
Schlageter, V.
Auteure/Auteur
Vesin, J.M.
Auteure/Auteur
Aellen, S.
Auteure/Auteur
Peloponissios, N.
Auteure/Auteur
D'Ambrogio, A.
Auteure/Auteur
Wiesel, P.H.
Auteure/Auteur
Givel, J.C.
Auteure/Auteur
Kucera, P.
Auteure/Auteur
Virag, N.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1521-6047[electronic], 0090-6964[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
38
Numéro
7
Première page
2398
Dernière page/numéro d’article
2405
Langue
anglais
Résumé
Direct electrical stimulation of the colon offers a promising approach for the induction of propulsive colonic contractions by using an implantable device. The objective of this study was to assess the feasibility to induce colonic contractions using a commercially available battery-operated stimulator (maximum pulse width of 1 ms and maximum amplitude of 10 V). Three pairs of pacing electrodes were inserted into the cecal seromuscular layer of anesthetized pigs. During a first set of in vivo experiments conducted on six animals, a pacing protocol leading to cecum contractions was determined: stimulation bursts with 1 ms pulse width, 10 V amplitude (7-15 mA), 120 Hz frequency, and 30-s burst duration, repeated every 2-5 min. In a second testing phase, an evaluation of the pacing protocol was performed in four animals (120 stimulation bursts in total). By using the battery-operated stimulator, contractions of the cecum and movement of contents could be induced in 92% of all stimulations. A cecal shortening of about 30% and an average intraluminal pressure increase of 10.0 +/- 6.0 mmHg were observed.
PID Serval
serval:BIB_1D36A2DECF0E
PMID
Date de création
2010-07-01T12:44:47.539Z
Date de création dans IRIS
2025-05-20T16:12:07Z