Titre
Whole-brain high-resolution metabolite mapping with 3D compressed-sensing SENSE low-rank <sup>1</sup> H FID-MRSI.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Klauser, A.
Auteure/Auteur
Klauser, P.
Auteure/Auteur
Grouiller, F.
Auteure/Auteur
Courvoisier, S.
Auteure/Auteur
Lazeyras, F.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1099-1492
Statut éditorial
Publié
Date de publication
2022-01
Volume
35
Numéro
1
Première page
e4615
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
There is a growing interest in the neuroscience community to map the distribution of brain metabolites in vivo. Magnetic resonance spectroscopic imaging (MRSI) is often limited by either a poor spatial resolution and/or a long acquisition time, which severely restricts its applications for clinical and research purposes. Building on a recently developed technique of acquisition-reconstruction for 2D MRSI, we combined a fast Cartesian <sup>1</sup> H-FID-MRSI acquisition sequence, compressed-sensing acceleration, and low-rank total-generalized-variation constrained reconstruction to produce 3D high-resolution whole-brain MRSI with a significant acquisition time reduction. We first evaluated the acceleration performance using retrospective undersampling of a fully sampled dataset. Second, a 20 min accelerated MRSI acquisition was performed on three healthy volunteers, resulting in metabolite maps with 5 mm isotropic resolution. The metabolite maps exhibited the detailed neurochemical composition of all brain regions and revealed parts of the underlying brain anatomy. The latter assessment used previous reported knowledge and a atlas-based analysis to show consistency of the concentration contrasts and ratio across all brain regions. These results acquired on a clinical 3 T MRI scanner successfully combined 3D <sup>1</sup> H-FID-MRSI with a constrained reconstruction to produce detailed mapping of metabolite concentrations at high resolution over the whole brain, with an acquisition time suitable for clinical or research settings.
PID Serval
serval:BIB_5F1681F8344C
PMID
Open Access
Oui
Date de création
2021-10-08T15:53:49.876Z
Date de création dans IRIS
2025-05-20T18:35:30Z
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Nom
34595791_BIB_5F1681F8344C.pdf
Version du manuscrit
preprint
Licence
https://creativecommons.org/licenses/by-nc/4.0
Taille
42.32 MB
Format
Adobe PDF
PID Serval
serval:BIB_5F1681F8344C.P001
Somme de contrôle
(MD5):ccaa87e9b14793f278c5d1a3a87f8f44