Titre
Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Michaeli, B.
Auteure/Auteur
Berger, M. M.
Auteure/Auteur
Revelly, J. P.
Auteure/Auteur
Tappy, L.
Auteure/Auteur
Chiolero, R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0261-5614
Statut éditorial
Publié
Date de publication
2007-02
Volume
26
Numéro
1
Première page
70
Dernière page/numéro d’article
7
Notes
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Feb
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
BACKGROUND & AIMS: Fish oil (FO) has been shown to modulate the acute and chronic inflammatory responses. Endotoxin (LPS) has been shown to mimic several aspects of sepsis. The study aimed at testing the effects of oral FO supplements in healthy subjects submitted to intravenous LPS on systemic and endocrine response. SUBJECTS AND METHODS: Fifteen healthy men (aged 26.0+/-3.1 years, BMI 23.8+/-1.9 kg/m2), were enrolled. Subjects were randomised to 3-4 weeks of oral FO supplementation (7.2 g/day, providing 1.1 g/day of 20:5 (n-3) and 0.7 g/day of 22:6 (n-3) fatty acids) or no supplementation and then submitted to endotoxin challenge: 2 ng/kg of LPS. All subjects were studied twice (placebo and LPS). Measurements: vital signs, energy expenditure (EE), glucose and lipid metabolism ((2)H2-glucose), plasma cytokines and stress hormones for 6 h after LPS or placebo. RESULTS: LPS caused cytokine release, fever, increases in heart rate, resting EE and substrate oxidation, plasma glucagon and glucose concentrations; the neuro-endocrine response was characterised by increased plasma stress hormones. FO significantly blunted fever, ACTH and cortisol plasma levels (no effect on cytokine release). FO blunted the peak norepinephrine after LPS. CONCLUSION: FO supplements blunted the endocrine stress response and the increase in body temperature, but had no impact on cytokine production after LPS. These findings conflict with the postulated anti-inflammatory effects of FO on arachidonic acid metabolism and cytokine release. These results suggest that FO may exert beneficial effects in sepsis though non-inflammatory which require further investigations.
Sujets
PID Serval
serval:BIB_31D2FCEB16A2
PMID
Open Access
Oui
Date de création
2008-01-24T12:36:33.620Z
Date de création dans IRIS
2025-05-20T18:48:26Z