Titre
CT-Derived Sarcopenia and Outcomes after Thoracoscopic Pulmonary Resection for Non-Small Cell Lung Cancer.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Hasenauer, A.
Auteure/Auteur
Forster, C.
Auteure/Auteur
Hungerbühler, J.
Auteure/Auteur
Perentes, J.Y.
Auteure/Auteur
Abdelnour-Berchtold, E.
Auteure/Auteur
Koerfer, J.
Auteure/Auteur
Krueger, T.
Auteure/Auteur
Becce, F.
Auteure/Auteur
Gonzalez, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2072-6694
Statut éditorial
Publié
Date de publication
2023-01-27
Volume
15
Numéro
3
Première page
790
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
We aimed to evaluate whether computed tomography (CT)-derived preoperative sarcopenia measures were associated with postoperative outcomes and survival after video-assisted thoracoscopic (VATS) anatomical pulmonary resection in patients with early-stage non-small cell lung cancer (NSCLC). We retrospectively reviewed all consecutive patients that underwent VATS anatomical pulmonary resection for NSCLC between 2012 and 2019. Skeletal muscle mass was measured at L3 vertebral level on preoperative CT or PET/CT scans to identify sarcopenic patients according to established threshold values. We compared postoperative outcomes and survival of sarcopenic vs. non-sarcopenic patients. A total of 401 patients underwent VATS anatomical pulmonary resection for NSCLC. Sarcopenia was identified in 92 patients (23%). Sarcopenic patients were predominantly males (75% vs. 25%; p < 0.001) and had a lower BMI (21.4 vs. 26.5 kg/m <sup>2</sup> ; p < 0.001). The overall postoperative complication rate was significantly higher (53.2% vs. 39.2%; p = 0.017) in sarcopenic patients and the length of hospital stay was prolonged (8 vs. 6 days; p = 0.032). Two factors were associated with postoperative morbidity in multivariate analysis: BMI and American Society of Anesthesiologists score >2. Median overall survival was comparable between groups (41 vs. 46 months; p = 0.240). CT-derived sarcopenia appeared to have a small impact on early postoperative clinical outcomes, but no effect on overall survival after VATS anatomical lung resection for NSCLC.
PID Serval
serval:BIB_581BE76163B4
PMID
Open Access
Oui
Date de création
2023-03-03T15:33:51.108Z
Date de création dans IRIS
2025-05-20T18:52:59Z
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Nom
cancers-15-00790.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.38 MB
Format
Adobe PDF
PID Serval
serval:BIB_581BE76163B4.P001
URN
urn:nbn:ch:serval-BIB_581BE76163B42
Somme de contrôle
(MD5):1536e89a8d3cd56864c9da32e4fab538