Titre
Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila.
Type
article
Institution
Externe
Périodique
Auteur(s)
Katanaev, V.L.
Auteure/Auteur
Solis, G.P.
Auteure/Auteur
Hausmann, G.
Auteure/Auteur
Buestorf, S.
Auteure/Auteur
Katanayeva, N.
Auteure/Auteur
Schrock, Y.
Auteure/Auteur
Stuermer, C.A.
Auteure/Auteur
Basler, K.
Auteure/Auteur
Liens vers les personnes
ISSN
1460-2075
Statut éditorial
Publié
Date de publication
2008
Volume
27
Numéro
3
Première page
509
Dernière page/numéro d’article
521
Langue
anglais
Résumé
The lipid-modified morphogens Wnt and Hedgehog diffuse poorly in isolation yet can spread over long distances in vivo, predicting existence of two distinct forms of these morphogens. The first is poorly mobile and activates short-range target genes. The second is specifically packed for efficient spreading to induce long-range targets. Subcellular mechanisms involved in the discriminative secretion of these two forms remain elusive. Wnt and Hedgehog can associate with membrane microdomains, but the function of this association was unknown. Here we show that a major protein component of membrane microdomains, reggie-1/flotillin-2, plays important roles in secretion and spreading of Wnt and Hedgehog in Drosophila. Reggie-1 loss-of-function results in reduced spreading of the morphogens, while its overexpression stimulates secretion of Wnt and Hedgehog and expands their diffusion. The resulting changes in the morphogen gradients differently affect the short- and long-range targets. In its action reggie-1 appears specific for Wnt and Hedgehog. These data suggest that reggie-1 is an important component of the Wnt and Hedgehog secretion pathway dedicated to formation of the mobile pool of these morphogens.
Sujets
PID Serval
serval:BIB_58A66452D292
PMID
Open Access
Oui
Date de création
2011-12-22T15:13:46.667Z
Date de création dans IRIS
2025-05-20T19:00:22Z
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Nom
BIB_58A66452D292.P001.pdf
Version du manuscrit
published
Taille
2.47 MB
Format
Adobe PDF
PID Serval
serval:BIB_58A66452D292.P001
Somme de contrôle
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