Titre
Multifocal epithelial tumors and field cancerization: stroma as a primary determinant.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Dotto, G.P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1558-8238
Statut éditorial
Publié
Date de publication
2014
Volume
124
Numéro
4
Première page
1446
Dernière page/numéro d’article
1453
Langue
anglais
Résumé
It is increasingly evident that cancer results from altered organ homeostasis rather than from deregulated control of single cells or groups of cells. This applies especially to epithelial cancer, the most common form of human solid tumors and a major cause of cancer lethality. In the vast majority of cases, in situ epithelial cancer lesions do not progress into malignancy, even if they harbor many of the genetic changes found in invasive and metastatic tumors. While changes in tumor stroma are frequently viewed as secondary to changes in the epithelium, recent evidence indicates that they can play a primary role in both cancer progression and initiation. These processes may explain the phenomenon of field cancerization, i.e., the occurrence of multifocal and recurrent epithelial tumors that are preceded by and associated with widespread changes of surrounding tissue or organ "fields."
PID Serval
serval:BIB_4CC757939171
PMID
Open Access
Oui
Date de création
2014-05-08T07:39:11.832Z
Date de création dans IRIS
2025-05-20T19:22:40Z