Titre
At the heart of programming: the role of micro-RNAs.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Siddeek, B.
Auteure/Auteur
Mauduit, C.
Auteure/Auteur
Yzydorczyk, C.
Auteure/Auteur
Benahmed, M.
Auteure/Auteur
Simeoni, U.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2040-1752
Statut éditorial
Publié
Date de publication
2018-12
Volume
9
Numéro
6
Première page
615
Dernière page/numéro d’article
631
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Epidemiological and experimental observations tend to prove that environment, lifestyle or nutritional challenges influence heart functions together with genetic factors. Furthermore, when occurring during sensitive windows of heart development, these environmental challenges can induce an 'altered programming' of heart development and shape the future heart disease risk. In the etiology of heart diseases driven by environmental challenges, epigenetics has been highlighted as an underlying mechanism, constituting a bridge between environment and heart health. In particular, micro-RNAs which are involved in each step of heart development and functions seem to play a crucial role in the unfavorable programming of heart diseases. This review describes the latest advances in micro-RNA research in heart diseases driven by early exposure to challenges and discusses the use of micro-RNAs as potential targets in the reversal of the pathophysiology.
Sujets
PID Serval
serval:BIB_489523D8D0B7
PMID
Date de création
2018-07-23T15:22:43.971Z
Date de création dans IRIS
2025-05-20T19:27:51Z