Titre
Elevation de la tension arterielle lors de chirurgie sous garrot pneumatique: un mecanisme independant de la renine? [Elevation of arterial pressure during surgery with a pneumatic tourniquet: an independent action of renin?]
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Magnusson, L.
Auteure/Auteur
Rebagliati, M.
Auteure/Auteur
Buchser, E.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0832-610X
Statut éditorial
Publié
Date de publication
1993-07
Volume
40
Numéro
7
Première page
596
Dernière page/numéro d’article
600
Notes
Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial --- Old month value: Jul
English Abstract
Journal Article
Randomized Controlled Trial --- Old month value: Jul
Résumé
The aim of this study was to evaluate the effectiveness of captopril for the prevention of the increase of arterial pressure during orthopaedic surgery requiring the application of lower limb tourniquets with balanced anaesthesia. Twenty consecutive patients were included in the study and were randomly divided into two groups. The first (n = 10) received 50 mg captopril orally together with the preanaesthetic medication, the second (n = 10) received a placebo at the same time. The different variables studied (arterial pressure, heart rate) were continuously measured. This study demonstrated that the pretreatment with captopril did not prevent an increase of the arterial pressure during the application of a tourniquet. The means of the systolic and diastolic arterial pressures at the end of the application of the tourniquet were 128/86 and 128/81 in the captopril group and the placebo group, respectively. This result shows that the renin-angiotensin system does not significantly contribute to the increase of the arterial pressure induced by a tourniquet.
Sujets
PID Serval
serval:BIB_0565F1B2468D
PMID
Open Access
Oui
Date de création
2008-01-28T09:51:58.952Z
Date de création dans IRIS
2025-05-20T19:30:26Z