Titre
Outcomes of disconnective surgery in intractable pediatric hemispheric and subhemispheric epilepsy.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Thomas, S.G.
Auteure/Auteur
Chacko, A.G.
Auteure/Auteur
Thomas, M.M.
Auteure/Auteur
Babu, K.S.
Auteure/Auteur
Russell, P.S.
Auteure/Auteur
Daniel, R.T.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1687-9759
Statut éditorial
Publié
Date de publication
2012
Volume
2012
Première page
527891
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish. pdf type: clinical study
Résumé
Objectives: To study the outcome of disconnective epilepsy surgery for intractable hemispheric and sub-hemispheric pediatric epilepsy. Methods: A retrospective analysis of the epilepsy surgery database was done in all children (age <18 years) who underwent a peri-insular hemispherotomy (PIH) or a peri-insular posterior quadrantectomy (PIPQ) from April 2000 to March 2011. All patients underwent a detailed pre surgical evaluation. Seizure outcome was assessed by the Engel's classification and cognitive skills by appropriate measures of intelligence that were repeated annually. Results: There were 34 patients in all. Epilepsy was due to Rasmussen's encephalitis (RE), Infantile hemiplegia seizure syndrome (IHSS), Hemimegalencephaly (HM), Sturge Weber syndrome (SWS) and due to post encephalitic sequelae (PES). Twenty seven (79.4%) patients underwent PIH and seven (20.6%) underwent PIPQ. The mean follow up was 30.5 months. At the last follow up, 31 (91.1%) were seizure free. The age of seizure onset and etiology of the disease causing epilepsy were predictors of a Class I seizure outcome. Conclusions: There is an excellent seizure outcome following disconnective epilepsy surgery for intractable hemispheric and subhemispheric pediatric epilepsy. An older age of seizure onset, RE, SWS and PES were good predictors of a Class I seizure outcome.
PID Serval
serval:BIB_0967A80E158E
PMID
Open Access
Oui
Date de création
2014-02-04T19:00:23.832Z
Date de création dans IRIS
2025-05-20T19:32:18Z
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Nom
BIB_0967A80E158E.P001.pdf
Version du manuscrit
preprint
Taille
5.11 MB
Format
Adobe PDF
PID Serval
serval:BIB_0967A80E158E.P001
URN
urn:nbn:ch:serval-BIB_0967A80E158E4
Somme de contrôle
(MD5):df2b7b43249ed94d9a08c4d5dfff977d